Journal of International Oncology››2020,Vol. 47››Issue (7): 428-430.doi:10.3760/cma.j.cn371439-20200401-00050

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Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment

Zhou Jiamin, Ye Lisha, Wang Guohua()

  1. Institute of Special Environmental Medicine, Nantong University, Nantong 226001, China
  • Received:2020-04-01Revised:2020-04-10Online:2020-07-08Published:2020-08-18
  • Contact:Wang Guohua E-mail:wgh@ntu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81471257);Primary Research and Development Plan of Jiangsu Province(BE2018778);The Fifth "333 Project" of Jiangsu Province(BAR2019207);Nantong Science and Technology Plan(MS12018029)

Abstract:

Tumor associated macrophage (TAM), as the main type of immune cells in tumor microenvironment, becomes an active participant in the development of breast cancer. MicroRNA (miRNA) can regulate post-transcriptional gene expression, modulation of macrophage function by affecting its polarization typing and transformation, and ultimately contribute to the occurrence and development of breast cancer. It could provide a new diagnosis and clinical treatment strategy for the treatment of breast cancer by summarizing the mechanisms of miRNA in the polarization of TAM.

Key words:Breast neoplasms,Tumor microenvironment,Macrophages,MicroRNAs