Journal of International Oncology››2021,Vol. 48››Issue (2): 113-116.doi:10.3760/cma.j.cn371439-20200610-00022

• Reviews •Previous ArticlesNext Articles

Advances of PD-1/PD-L1 inhibitors in the treatment of esophageal squamous cell carcinoma

Ding Yan, Wang Hongyan()

  1. Department of Radiation Oncology, First Affiliated Hospital of Anhui Medical University, Hefei 230000, China
  • Received:2020-06-10Revised:2020-06-21Online:2021-02-08Published:2021-03-11
  • Contact:Wang Hongyan E-mail:whhy5000@163.com
  • Supported by:
    Natural Science Research Project of Colleges and Universities of Anhui Province of China(KJ2016A341);Teaching Research Project of Anhui Province of China(2019jyxm0994)

Abstract:

Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of the confirmed cases of esophageal cancer in Asia, and the degree of malignancy is high. There is a growing number of research on ESCC immunotherapy, particularly programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1). Among them, the most studied PD-1/PD-L1 inhibitors in ESCC are nivolumab, pembrolizumab, camrelizumab, toripalimab, tislelizumab, atozolizumab, SHR-1316 and durvalumab. Some of the clinical trials of these drugs are still in progress, and some have initially shown good results.

Key words:Esophageal neoplasms,Neoplasms, squamous cell,PD-1,PD-L1