Journal of International Oncology››2013,Vol. 40››Issue (12): 896-899.doi:10.3760/cma.j.issn.1673-422X.2013.12.005

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Y-box-binding protein 1 and epithelialmesenchymal transition

YAN Xue-Bing, ZHU Qing-Chao, JIN Zhi-Ming

  1. Department of General Surgery, Affiliated Sixth People′s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-12-10Published:2013-12-26
  • Contact:JIN Zhi-Ming E-mail:jzmgyp@aliyun.com

Abstract:In the process of epithelialmesenchymal transition (EMT), cellcell adherence is disrupted, apicobasal polarity is lost, the ability of antiapoptosis, migration and invasion is acquired. Yboxbinding protein 1 (YB1) is a member of the coldshock protein superfamily, containing a structurally and functionally conserved cold shock domain. Studies indicate that YB1 can promote the occurrence and development of tumors by regulating EMT. In the process of EMT mediated by YB1, various transcription factors and signal pathways play important roles.

Key words:Yboxbinding protein 1,Cell transformation, neoplastic,Transcription factors,Signal transduction