Expressions and clinical significances of microRNA-126 and microRNA-7 in esophageal squamous cell carcinoma

Abstract

Abstract:ObjectiveTo detect the expressions of microRNA126 (miR126) and microRNA7 (miR7) in esophageal squamous cell carcinoma (ESCC) and to analyze their correlations with clinicopathologic features and prognosis of ESCC. MethodsThe expressions of miR126 and miR7 in 116 ESCC samples and matched normal tissue samples were detected by realtime PCR. Statistical analysis was used to find the relationships among the expressions of miR126 and miR7, pathological characteristics and prognosis. ResultsLow expression, normal expression and high expression of miR126 were found in 73 (62.9%), 35 (30.2%) and 8 (6.9%) carcinoma samples respectively. Low expression, normal expression and high expression of miR7 were found in 52 (44.8%), 35 (30.2%) and 29 (25.0%) carcinoma samples respectively. The diseasefree survival in patients with low expression of miR126 and miR7 was shorter than that in patients with nonlow expression (χ2=4.268, P＜0.05; χ2=4.993, P＜0.05). The low expression of miR126 was correlated with tumor location, family history and drinking (χ2=14.564, P＜0.05; χ2=5.691, P＜0.05; χ2=4.971, P＜0.05), but was uncorrelated with gender, age, differentiation, infiltration, lymphatic metastasis and smoking (all P＞0.05). The low expression of miR7 was uncorrelated with pathological characteristics of ESCC (all P＞0.05). Conclusion The low expressions of miR126 and miR7 may be related to the prognosis of patients with ESCC, and have a certain clinical detection significance.

Key words:Esophageal neoplasms,Prognosis,MicroRNA-126,MicroRNA-7

WANG Jiang-Feng, LING Zhi-Qiang, MAO Wei-Min. Expressions and clinical significances of microRNA-126 and microRNA-7 in esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2013, 40(12): 936-940.

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