Journal of International Oncology››2015,Vol. 42››Issue (4): 274-276.doi:10.3760/cma.j.issn.1673-422X.2015.04.009

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Angiotensin-(1-7) and tumors

  1. School of Medical and Life Sciences, Shandong Academy of Medicine Sciences, Jinan University & Department of Radiotherapy, Shandong Cancer Hospital, Jinan 250117, China
  • Online:2015-04-08Published:2015-04-22
  • Contact:Yu Jinming, Email: sdyujinming@126.com

Abstract:Angiotensin-(1-7) [Ang-(1-7)] is an endogenous peptidehormone of the reninangiotensin system. Ang-(1-7), angiotensinconverting enzyme 2 (ACE2) and MAS receptor constitute ACE2Ang-(1-7)Mas axis, which antagonizes the ACEAngⅡAngⅡ type 1 receptor axis. Recent studies indicate that Ang-(1-7) has certain effects on treating tumors, including inhibition of angiogenesis, anticell proliferation and inhibition of tumor fibrosis. Researches on the roles and mechanisms of Ang-(1-7) can provide new target for treatment and prevention of cancer.

Key words:Neoplasms,Angiotensin-(1-7)