Journal of International Oncology››2017,Vol. 44››Issue (6): 448-.doi:10.3760/cma.j.issn.1673-422X.2017.06.012

Previous ArticlesNext Articles

Mechanism of anti-tumor effect of dihydroartemisinin

Peng Wenmiao, Fu Hongxing, Yu Lifang, Rao Zhiguo

  1. Department of Oncology, Wuhan General Hospital of Guangzhou Military, Wuhan 430070, China
  • Online:2017-06-08Published:2017-06-16
  • Contact:Rao Zhiguo E-mail:raozhiguo@hotmail.com
  • Supported by:

    Natural Science Foundation of Hubei Province of China (2014CFC1049)

Abstract:Dihydroartemisinin (DHA), the major active metabolite of artemisinin, participates in tumor progression through the following ways: forming free radicals to induce cancer cells death dependent on iron, inducing apoptosis, inhibiting angiogenesis, tumor cells invasion and metastasis, modulating multidrug resistance, controlling intracellular Ca2+ concentration, regulating cell cycles, cell autophagy and the immune system and so on. Generally, it is considered to be a potential antitumor drug.

Key words:Artemisinins,Neoplasms,Apoptosis,Cell proliferation,Dihydroartemisinin