Abstract:ObjectiveTo investigate the expression and clinical significance of long non-coding RNA (lncRNA) RP11629B11.4 in triple negative breast cancer (TNBC) patients. MethodsThe expression of lncRNA RP11629B11.4 was detected by real-time fluorescent quantitative polymerase chain reaction (qRT-PCR) in TNBC tissues （n=45） and non triple negative breast cancer (N-TNBC， n=89) to analyze the relationship between the expression of lncRNA RP11-629B11.4 and the prognosis of patients. ResultsThe expression of lncRNA RP11-629B11.4 in TNBC tissues was 7.805±0.538, significantly higher than that in N-TNBC tissues (1.637±0.409, t=21.460, P＜0.001). The expression of lncRNA RP11-629B11.4 in the TNBC patients was related with histological grade (χ2=7.540, P=0.040), clinical stage (χ2=9.858, P=0.007), lymph node metastasis (χ2=4.388, P=0.036) and Ki-67 expression (χ2=7.872, P=0.005). In the N-TNBC group, there was no significant correlation between the expression of lncRNA RP11-629B11.4 and clinicopathological characteristics (all P＞0.050). The progression free survival time of TNBC patients with higher expression of lncRNA RP11-629B11.4 was (15.90±2.76) months, shorter than that of patients with lower expression (26.62±3.80) months, with a statistically significant difference (χ2=49.750, P＜0.001). The overall survival time of TNBC patients with lower expression of lncRNA RP11-629B11.4 was (38.84±3.55) months, significantly longer than that of patients with higher expression ［(24.69±3.50) months］, with a statistically significant difference (χ2=50.730, P＜0.001). Cox regression model analysis showed that lymph node metastasis (HR=1.980, P=0.019), the expression of lncRNA RP11-629B11.4 (HR=4.030, P＜0.001)clinical stage (HR=2.670, P=0.008) and were independent prognostic factors in patients with TNBC. ConclusionThe lncRNA RP11629B11.4 is over-expressed in TNBC. lncRNA RP11-629B11.4 may be involved in the regulation of TNBC, and it may be used as a potential target for evaluating the prognosis of TNBC.

Key words:Breast neoplasms,Prognosis,Long non-coding RNA RP11-629B11.4