Journal of International Oncology››2019,Vol. 46››Issue (1): 49-53.doi:10.3760/cma.j.issn.1673-422X.2019.01.011

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Progress of radiotherapy combined with anti-PD-1/PD-L1 in tumor therapy

Li Hui1, Duan Yongjian1, Ge Hong2

  1. 1河南大学第一附属医院肿瘤科,开封475001;2河南省肿瘤医院放疗科,郑州450008
  • Received:2018-11-14Online:2019-01-08Published:2019-04-03
  • Contact:Duan Yongjian E-mail:dyj9062@163.com
  • Supported by:

    National Natural Science Foundation of China (81472745)

Abstract:Radiotherapy is widely used in local treatment of tumors. It can not only directly kill tumor cells by damaging DNA, but also have a great impact on the immune system of the body. This effect is not only inhibited, but also more activated. Programmed death1 (PD1) and its ligand 1 (PDL1) antibody, as the most popular immune checkpoint inhibitor, can inhibit tumor growth by restoring and enhancing the immune killing function of T cells. With the deepening of the study, it is found that the combination of the two treatment of tumor, the curative effect is better than the single mode.

Key words:Radiotherapy,Immunotherapy,PD-1,PD-L1