Molecular alterations in precancerous lesions of esophageal squamous cell carcinoma

Abstract

Abstract:Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. ESCC develops gradually from the precancerous lesions. The researches about biomarkers mainly concentrate in the nucleic acid and protein, including cytogenetic abnormalities, amplifications, deletions, mutations, breakage and fusions of genomic DNA, expression changes of mRNA, microRNA (miRNA) and long noncoding RNA (lncRNA) in RNA level, and expression level, subcellular localization, and posttranslational modifications of proteins. Studies on the molecular alterations in precancerous lesions and early cancer of t he esophagus will contribute to the exploration of biomarkers for early diagnosis and intervention targets for this disease.

Key words:Esophageal neoplasms,Neoplasms, squamous cell,DNA,RNA,Proteins,Precancerous lesions

Chang Chen, Wang Mingrong. Molecular alterations in precancerous lesions of esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2019, 46(7): 430-433.

References

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