Abstract:High mobility group protein A1 (HMGA1) are members of a superfamily of non-histone chromatin proteins, which exist widely in eukaryotic nuclei and are mainly involved in transcriptional regulation of gene expression. Recent researches show that almost all human malignant tumors have abnormal expression of HMGA1, which may have an important role in the development of cancer, but the exact mechanism is not clear yet. In cancer research, transfection system which constructed on the basis of HMGA1 will have potential value, and also could shed some light on the treatment of cancer.