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08 October 2011, Volume 38 Issue 10 Previous IssueNext Issue

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Cell-based delivery of oncolytic viruses XU Zun-You, MAO Li-Jun, CHEN Jia-Cun 2011, 38 (10): 723-725. Abstract( 617) PDF(704KB) ( 1827) Save Oncolytic viruses, a novel class of virus vectors, which selectively replicate only in tumor cells, have excellent tumor targeting and good tansfection efficiency. Many oncolytic viruses have apparent curative effect when administered intratumorally. However, the host immune system remains a critical obstacle to systemic administration of virotherapeutics. It appears that cell-based delivery of oncolytic viruses could offer one solution to this critical problem, which provides a new platform to the biological therapy of cancer. Related Articles|Metrics

Function of SOCS1 in DC-based tumor vaccines XU Ying-Yi, CHEN Yu-Qiang 2011, 38 (10): 729-732. Abstract( 787) PDF(700KB) ( 1825) Save Dendritic cells (DC) are the important auxiliary cells in tumor vaccines to activate antitumor immunity. Suppressor of cytokine signaling 1 (SOCS1) has been shown to play an important role in inhibition of cytokine signal transduction. Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity, and in the methods of restraining SOCS1's function have also made significant progress. Related Articles|Metrics

Tumor-related miRNA targeting PTEN YANG Shuo, GAO Ai 2011, 38 (10): 732-735. Abstract( 693) PDF(686KB) ( 1745) Save MicroRNAs are the endogenous non-coding RNAs that regulate gene expression by mediating gene post-transcriptional silence. Among them, miR-21, miR-17-92, miR-214, miR-26a, miR-221, miR-222 and so on mainly suppress the expression of PTEN phosphohydrolase through targeting PTEN mRNA 3’-UTR. PTEN plays an important role in cell proliferation, apoptosis, migration and invasion, and its low expression will induce tumorigenesis. Related Articles|Metrics

ATF4 in malignant tumors anddrug resistance ZHANG Zhu-Hong, FU Zhi-Yan, LIU Cheng-Hu 2011, 38 (10): 735-737. Abstract( 711) PDF(627KB) ( 1990) Save Activating transcription factor 4 (ATF4), one of the activatingtranscription factors, belongs to the cyclic AMP response element binding protein family. The expression of ATF4 is up-regulated by tumor micro-environmental factors. And ATF4 regulates the processes of tumor growth, infiltration, metastasis, apoptosis and drug resistance. Therefore, ATF4 might serve as a potential therapeutic target in cancer. Related Articles|Metrics

Mechanism and abnormal expression of the sox4 gene in tumor ZHOU Yong-Chun, WANG Xi-Cai, HUANG Yun-Chao 2011, 38 (10): 738-741. Abstract( 993) PDF(714KB) ( 2572) Save Recent studies revealed that sox4geneexpresses abnormally in many kinds of tumor tissues and it probably involved in tumorigenesis, development and metastasis of cancer. Regulating proliferation, differentiation, apoptosis and other process may participate in the work mechanisms of sox4gene. Therefore, further studies about the relationship between sox4 gene and tumor would provide new ideas of exploring special diagnosis marker and novel target for tumor therapy. Related Articles|Metrics

Role of macrophage migration-inhibitory factor in cancer ZHANG Hong-Bo, LIU Jin 2011, 38 (10): 741-744. Abstract( 777) PDF(705KB) ( 1776) Save Macrophage migration-inhibitory factor (MIF) is a cytokine which can promote tumorigenesis. MIF can promote tumorigenesis by directly inducing oncogene transformation, stimulating cell division, as well as indirectly inhibiting tumor apoptosis, promoting its invasiveness and angiogenesis. MIF-targeted biological therapy may become a new therapeutic strategy for malignant tumor. Related Articles|Metrics

Function and mechanism of the high mobility group protein A1 in tumor ZHOU Rui, WANG Sheng-Ying 2011, 38 (10): 744-747. Abstract( 667) PDF(700KB) ( 1831) Save High mobility group protein A1 (HMGA1) are members of a superfamily of non-histone chromatin proteins, which exist widely in eukaryotic nuclei and are mainly involved in transcriptional regulation of gene expression. Recent researches show that almost all human malignant tumors have abnormal expression of HMGA1, which may have an important role in the development of cancer, but the exact mechanism is not clear yet. In cancer research, transfection system which constructed on the basis of HMGA1 will have potential value, and also could shed some light on the treatment of cancer. Related Articles|Metrics

MACC1 and tumor metastasis ZHANG Min, REN De-Lian 2011, 38 (10): 747-750. Abstract( 725) PDF(636KB) ( 1726) Save Recent findings indicate that metastasis-associated gene in colon cancer 1 (MACC1) has an abnormal high expressionin most malignant tumors. As a key regulator of HGF-MET signal pathway, MACC1 could obviously up-regulate the expression of MET and promote cancer cell’s movement, invasion and metastasis. Further studies will shed light onelucidating the mechanisms of metastasis and may provide a new method for targeted therapy. Related Articles|Metrics

Advances in the methods of acquiring tumor antigens FANG Xiao-Rui, HAO Ping 2011, 38 (10): 750-753. Abstract( 727) PDF(741KB) ( 1873) Save How to acquire new tumor antigens is a hotspot in cancer research currently. According to the nature of antigen epitope binding its ligand, we can identify and get unknown antigen epitopeeven its amino acid sequence through some analytical techniques and experiments, from T lymphocytes and monoclonal antibody levels. So the molecular mechanisms of tumor immunity will be more distinct. Related Articles|Metrics

Cryoablation and anti-tumor immune response SONG Chun-Hui, ZHAO Wen-Hua, LIU Yuan-Shui 2011, 38 (10): 753-756. Abstract( 744) PDF(649KB) ( 1898) Save Cryoablation, a kind of physical ablation for tumor treatment, is minimally invasive, safe and effective. Studies suggest that cryoablation can not only kill tumor cells directly, but also the anti-tumor immune response triggered by cryoablation plays an important role in inhibiting the growth of local tumors and eliminating the residual tumor cells. Related Articles|Metrics

Clinical application of proton magnetic resonance sectroscopy in glioma SUN Jiu-Bo, HAO Jun-Fang 2011, 38 (10): 756-758. Abstract( 724) PDF(636KB) ( 1798) Save Proton magnetic resonance spectroscopy（HMRS） is the only way to study noninvasively the metabolic and biochemical signature of the human tissues and organs. It can alsoquantify the metabolites within the volume of interest. The metabolic information about the lesions provided by the HMRS can greatly improve the diagnostic, grading accuracy, treatment planning such as target delineation and posttreatment follow-up of the glioma. Related Articles|Metrics

Role of n-3 polyunsaturated fatty acid in the combined treatment of breast cancer ZHANG Feng, CHEN Yi-Ding 2011, 38 (10): 758-761. Abstract( 784) PDF(712KB) ( 1853) Save Breast cancer is a type of heterogenetic neoplasm. Metabolic dysfunction plays a pivotal role in the pathogenesis and progress of breast cancer. N-3 polyunsaturated fatty acid (PUFA) could change fatty acid metabolism of breast cancer cells and modulate expression of oncogenes and anti-oncogenes through various ways. It may provide therapeutic opportunities in the treatment of chemotherapy, radiotherapy, endocrine therapy and molecule targeted therapy of breast cancer. Related Articles|Metrics

Lung cancer stem cells JIANG Mei, YUE Wen-Tao 2011, 38 (10): 761-763. Abstract( 722) PDF(722KB) ( 1812) Save Recently, studies have demonstrated that several signaling pathways including Wnt, Notch, and Hedgehog which are involved in the regulation of the stem cells are abnormally activated in lung cancer. They are closely associated with some properties of the lung cancer stem cells, such as high tumorigenic, high metastasis, drug resistance and so on. In addition, several studies have shown that the population of the lung cancer stem cells, which are resistant to radiotherapy and chemotherapy significantly, highly express drug resistance proteins. Therefore, how to target lung cancer stem cells and ultimately cure the disease is becoming a hotspot in the cancer targeted therapy. Related Articles|Metrics

Prediction of response to chemotherapy and (or) radiotherapy in locally advancednon–small cell lung cancer with18F-FDG PET-CT ZHU Shou-Hui, YU Yong-Hua, ZHANG Yong 2011, 38 (10): 764-767. Abstract( 631) PDF(697KB) ( 1640) Save 18F-FDG PET-CT has been widely used for the diagnosis, staging and assessment of therapeutic response in patients with non-small cell lung cancer (NSCLC). In particular, the technique plays an important role in the prediction of the response to therapy in patients with locally advanced NSCLC. It can dynamically observe the tumor tissue metabolism, and according to the changes of 18F-FDG uptake by visual or quantitative analysis, before and after treatment, allow prediction of the early efficacy of locally advanced NSCLC with chemotherapy and (or) radiotherapy in clinical or sub-clinical levels. Related Articles|Metrics

Consolidation chemotherapy following concurrentchemoradiationtherapy for the locally advanced inoperable non-small cell lung cancer YU Xu-Juan, CHEN Zhi-Jian 2011, 38 (10): 767-770. Abstract( 685) PDF(694KB) ( 1883) Save Concurrent chemoradiation therapy is currently a recommended treatment approach for locally advanced inoperable stage IIIA and stage IIIB non-small cell lung cancer (NSCLC). There is no consensus on the optimal treatment regimen. It is one of these options for the consolidation chemotherapy following concurrent chemoradiation therapy. To date, there is no sufficient evidence indicating that consolidation chemotherapy following concurrent chemoradiation therapy further improves survival rates. The benefit remains to be confirmedby more clinical test. Related Articles|Metrics

Application of magnetic resonance imaging diffusion weighted imaging in lung cancer ZHANG An-Du, HAN Chun 2011, 38 (10): 771-774. Abstract( 794) PDF(734KB) ( 1768) Save Magnetic resonance imaging diffusion weighted imaging（DWI）as a non-radiation and non-invasive examination method, has great help in diagnosis and staging of lung cancer, and the apparent diffusion coefficient (ADC) determination has demonstrated clinical application value in the therapeuticassessment. As an essential complement of CT, MRI-CT imaging infusion improves the accuracy of the target volume sketching in the radiotherapy of lung cancer. Related Articles|Metrics

Biological markers of esophageal carcinoma invasion and metastasis FAN Xiao-Ling, LIU Wen-Qi 2011, 38 (10): 774-776. Abstract( 704) PDF(655KB) ( 1796) Save The invasion and metastasis of esophageal carcinoma is associated with several tumor marker on oncogenesi and tumor development, including matrix metalloproteinase, cell adhesion molecules CD44,pituitary-tumour transforming genes.Studies have shown that these tumor markera are over-expression in esophageal carcinoma, which affect the progress and prognosis of esophageal carcinoma , and their specificity and value for clinical application need to be futher studied Related Articles|Metrics

Progress on the study ofpredictingradiosensitivity of esophageal carcinoma CHEN Bo, YIN Li-Liang, FAN Ling-Li, et al 2011, 38 (10): 777-780. Abstract( 701) PDF(725KB) ( 1606) Save The radiosensitivity of esophageal carcinoma is one of the bases for makingdividualized treatment program. Predition of radiosensitivity before radiotherapy has become a hot spot of the current study. It has been demonstrated that radiosensitivity of esophageal carcinoma is correlated to p53 portein, bcl-2 portein, human epidermal growth factor receptors(hEGFR), vascular endothelial growth factor(VEGF), hypoxia-inducible-factor 1(HIF-1）, cyclooxygenase-2(COX-2) and so on. Detection of these markers may be helpful for predicting the radiosensitivity of esophageal carcinonla and making optimal treatment program. In addition, radiosensitivity of tumor can be predicted according to radiation-induced esophagitis grade and endiscopic uhrasonography(EUS). Related Articles|Metrics

18F-FDG PET-CT in staging of esophageal carcinoma SUN Ming-Ping, LI Bao-Sheng 2011, 38 (10): 780-783. Abstract( 782) PDF(699KB) ( 1294) Save A hybrid 18F-FDG positron emission tomography and computed tomography ( 18F-FDG PET-CT) image can offer the functional and anatomic information simultaneously. Compared with conventional methods, such as CT, EUS, it has advantages in determining the TNM staging, especially in measuring the length of primary tumor and detecting the metastasis of distant lymph nodes and organs. Moreover, it can guide the treatment and evaluate therapeutic effect of esophageal carcinoma. Related Articles|Metrics

Melanoma antigen A and hepatocellular carcinoma ZHANG Yong-Jun, ZHANG Wen-Min 2011, 38 (10): 783-786. Abstract( 817) PDF(716KB) ( 1565) Save Melanoma antigen A is a kind of tumor-associated antigen, which expresses in various types of hunman malignant tumor tissues especially in melanoma. Hepatocellular carcinoma (HCC) is a kind of malignant epithelialtumor with high incidence which occurs in liver. Searching foreffective diagnosis and treatment methods of it become a pressing task. It is confirmed that MAGE-A gene is highly expressed in HCC tissues which has great significance to the diagnosis, treatment and prognosis for HCC. Related Articles|Metrics

MicroRNA in cervical cancer and precancerous lesion HU Xiao-Xia, LI Li 2011, 38 (10): 787-790. Abstract( 883) PDF(700KB) ( 1853) Save MicroRNAs (miRNAs) are a class of small, non-coding, single-stand RNA molecules which are composed of 21～25 ribonucleotides. They regulate gene expression at post-transcription and participate in many important biological processes including cell growth, apoptosis, viral infection and cancer development. At present, the studies on miRNAs in cervical lesion include miRNAs expression characteristic of cervical cancer and precancerous lesion, the association with HPV infection and prognosis of cervical lesion, cervical cancer development，diagnosis and therapy. Related Articles|Metrics

Function of microRNAs in ovarian cancer ZHANG Chun-Jie, LI Na, JIN Ping 2011, 38 (10): 790-793. Abstract( 698) PDF(717KB) ( 1773) Save The expression of microRNAs (miRNAs) alters obviously in ovarian cancer. Through miRNA profile based on a microarray platform and further research on individual one, they are found to be closely related to pathogenesis, progression, recurrence, and drug resistance of ovarian cancer and have a good prospect in applying itin the early diagnosis, detection recurrence, prognosis and therapy ofovarian cancer. Related Articles|Metrics

Cell cycle arrest and cell apoptosis induced by Vpr in cancer cells in vitro TONG Jia-Bei, HAN Jin-Xiang, LU Yan-Qin 2011, 38 (10): 794-797. Abstract( 822) PDF(2064KB) ( 1797) Save Objective To investigate the G 2cell cycle arrest and apoptosis induced by HIV-1 Vpr gene on Hela、Lovo and HepG2 cancer cells. Methods Recombinant vector pcDNA4 –vpr was constructed by DNA recombination technology and was then transfected into Hela, Lovo and HepG2 cells. Meanwhile, pcDNA4 –EGFP plasmid group, FUGENE group and blank group was also setup as control. Ratio of cytostasis was evaluated by MTS assay 24h, 48h and 72h later, cell cycle arrest examined by flow cytometry and apoptosis detected by staining with ANNEXIN V and PI double dyes. Results Compared to the control group, the value of inhibition ratio, G 2arrest and apoptosis of Hela, Lovo and HepG2 cells increased obviously 24h, 48h and 72h after the transfection ( P<0.05). 72h after the transfection, the inhibition ratio of Hela, Lovo and HepG2 was 29.67%, 27.35% and 31.67% respectively. Percentage of G 2phase cells was 24.9%, 18.8% and 32.1% respectively. Apoptosis percentage of Hela, Lovo and HepG2 cells was 15.46%, 7.7% and 41.5% correspondingly. Conclusion HIV-1 vpr gene can induce cell cycle G 2arrest and apoptosis of Hela, Lovo and HepG2 cell line in vitro. Related Articles|Metrics

Application of diffusion tensor imaging in brain tumors LI Wei, LONG Wan-Sheng, LUO Xue-Mao, et al 2011, 38 (10): 797-800. Abstract( 571) PDF(872KB) ( 1783) Save Objective To study the characteristics of diffusion tensor imaging (DTI) in brain tumor and it's diagnosis and differential diagnosis value. Methods Thirty-nine patients with brain tumors proven by pathologically (10 meningioma, 17 glioma, 12 metastatic tumors), using Philips Achieva 1.5 T MRI, conventional MRI and DTI were underwent on them, fractional anisotropy (FA) maps, apparent diffusion coefficient (ADC) maps and three dimensional white matter fiber bundle map were reconstructed in the workstation, selected the core substance of the tumor area and the contralateral mirror area as the region of interest, measured FA and ADC values of them, and t test was performed, P＜0.05 was regarded asthe difference have statistically significant. Results The FA values of meningioma, metastases tumors and gliomas were 0.36±0.08, 0.28±0.03, 0.18±0.06, respectively, meningioma is the highest, followed by metastases tumors, and gliomas is the lowest. FA values between meningiomas and metastases tumors, meningiomas and gliomas, metastases tumors and gliomas had significant differences ( P＜0.05). The ADC values of meningioma, metastases tumors and gliomas were 1.72±0.10, 1.52±0.22, 1.34±0.14, respectively, meningioma is the highest, followed by metastases tumors, and gliomas is the lowest. ADC values between meningiomas and metastases tumors, meningiomas and gliomas, metastases tumors and gliomas had significant differences ( P＜0.05). Conclusion DTI has high clinical value in identification of meningiomas, metastatic tumors and glioma. Related Articles|Metrics