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Chemokine CCL18 and tumor JIANG Xiao, XIA Juan, CHENG Bin Journal of International Oncology 2014, 41 (10): 724-726. DOI:10.3760/cma.j.issn.1673-422X.2014.10.002 Abstract（ 1187） PDF（pc）（678KB）（ 11634） Knowledge map Save Chemokine CCL18 plays significant roles in immune regulation by recruiting of inflammatory cells, which involves in immune and inflammatory processes. CCL18 protein is overexpressed in the serum of patients with cancer and some tumor tissues. However, it is still controversial that CCL18 plays the role of tumor promoter or tumor suppressor. Researches on the roles and mechanisms of CCL18 can provide new target for diagnosis and treatment of cancer. Reference|Related Articles|Metrics|Comments（0）

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Expressions and clinical significances of TK1 and Ki-67 in triple negative breast cancer Niu Yuchao*, Yao Yuan, Ma Xuezhen Journal of International Oncology 2016, 43 (6): 409-413. DOI:10.3760/cma.j.issn.1673-422X.2016.06.003 Abstract（ 924） PDF（pc）（924KB）（ 7226） Knowledge map Save Objective To analyze the expressions of thymidine kinase 1 (TK1) and nuclearassociated antigen Ki-67 in triple negative breast cancer (TNBC) and their clinical significances. MethodsOne hundred and twenty tumor tissue sections of patients with breast cancer who were performed breast conservation treatment or modified mastectomy in the Second Affiliated Hospital of Qingdao University Medical College from June 2009 to December 2010 were collected, and there were 60 cases with TNBC and 60 cases with nonTNBC. The expressions of TK1 and Ki-67 in different breast tissues were detected by immunohistochemistry. The relationships between the expression status and clinicopathologic features were analyzed. ResultsThe positive expression rates of TK1 in TNBC and nonTNBC were 83.33% and 51.67% respectively, with a significant difference (χ2=13.713, P=0.000). The positive expression rates of Ki67 expression in TNBC and nonTNBC were 68.33% and 31.67% respectively, with a significant difference (χ2=16.133, P=0.000). In TNBC, the expression of TK1 was related to histological staging (χ2=6.125, P=0.013), but it was not related to onset age (χ2=0.809, P=0.369), menopausal stutas (χ2=1.615, P=0.204), tumor size (χ2=0.054, P=0.816) and lymphatic metastasis (χ2=0.672, P=0.412). In TNBC, the expression of Ki67 was related to histological staging (χ2=13.145, P=0.000) and lymphatic metastasis (χ2=6.182, P=0.013), but it was not related to menopausal stutas (χ2=1.018, P=0.313), onset age (χ2=2.377, P=0.123) and tumor size (χ2=2.401, P=0.121). The expression of TK1 was positively correlated with that of Ki67 (r=0.369, P=0.023). The results of survival analysis showed that the diseasefree survival rates of 5year were 28.20% and 66.70% in the TK1 positive group and TK1 negative group, and the diseasefree survival rates of 5year were 24.30% and 64.30% in the Ki-67 positive group and Ki-67 negative group, with significant differences (χ2=4.194, P=0.041; χ2=4.540, P=0.033). ConclusionTK1 and Ki-67 are highly expressed in TNBC, and their expressions are correlated with histological staging and survival, which are expected to become prognostic indicators. Reference|Related Articles|Metrics|Comments（0）

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LI Hai-Dong, QIU Zheng-Jun Journal of International Oncology

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M2 macrophage marker CD206 and tumor Li Yue, Gao Lei, Li Hongchang, Yu Hongjie, Zhang Yong Journal of International Oncology 2019, 46 (3): 174-177. DOI:10.3760/cma.j.issn.1673-422X.2019.03.009 Abstract（ 13776） PDF（pc）（631KB）（ 4687） Knowledge map Save Tumorassociated macrophages exist in all stages of tumor progression, and stimulate angiogenesis and invasion of tissues. M2 macrophages are predominant. CD206 is a M2 macrophage marker with high specificity and plays an important role in tumor cell proliferation and metastasis. Studies have shown that CD206 is closely related to malignant tumors such as breast cancer, ovarian cancer, pancreatic cancer and prostate cancer. Deepening the research on CD206 has certain clinical guiding significance for expounding the formation mechanism of tumor immune microenvironment and finding more targeted drugs. Reference|Related Articles|Metrics|Comments（0）

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MA Li, HAN Xiao-Hong, SHI Yuan-Kai Journal of International Oncology

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XU Yong-Hong, LIU Qi Journal of International Oncology

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ZHAO Shu, ZHANG Ming-Hui, ZHANG Qing-Yuan Journal of International Oncology

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ZHANG Xin-Ming, GAO Wei, PAN Qi Journal of International Oncology

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GAO Wei, LIU Shang-Mei Journal of International Oncology 2011, 38 (8): 693-696. Abstract（ 854） PDF（pc）（704KB）（ 4245） Knowledge map Save Related Articles|Metrics|Comments（0）

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Breast cancer molecular subtypes and its clinical significance YU Shuang-quan Journal of International Oncology 2012, 39 (6): 432-435. Abstract（ 1814） PDF（pc）（698KB）（ 4230） Knowledge map Save Breast cancer is regarded as a heterogenous disease classified into different molecular subtypes, resulting in different biologic behavior and sensitivity to treatment respectively. Molecular biology typing that based gene expression profiles and biological characteristics of breast cancer can reflect the biological behavior of tumors exactly, which has important clinical significance. Related Articles|Metrics|Comments（0）

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Anticancer based on glycolysis pathway in tumor cells WANG Qian-Qian, GUAN Quan-Lin, ZHU Bing-Dong Journal of International Oncology 2011, 38 (12): 914-916. Abstract（ 1000） PDF（pc）（1194KB）（ 4148） Knowledge map Save Related Articles|Metrics|Comments（0）

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LIN Zhi-Guang, CHEN Bo-Bin Journal of International Oncology

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Chemotherapies and molecularly targeted therapies inbiliary tract cancers LIU Yan, LIU Wei Journal of International Oncology 2013, 40 (1): 72-74. Abstract（ 1019） PDF（pc）（774KB）（ 3808） Knowledge map Save Biliary tract cancer (BTC), which is a malignant tumor which originates from biliary epithelia. Most patients with BTC presentlocally advanced stage or distant metastasis. Although the standard systemic chemotherapy approaches are emerging, the prognosis remains poor. Combination of gemcitabine and cisplatin can significantly prolong survival for patients, which is the standard treatment for locally advanced or metastatic BTCs. Application of molecularly targeted therapies in advanced BTC is the new trend of clinical research. Related Articles|Metrics|Comments（0）

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CHEN Sheng-Min, PAN Xiao-Lin, LI Feng Journal of International Oncology

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CHEN Zu-Jin, ZHANG Bin, CAO Xu-Chen Journal of International Oncology

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CAO Xiu-Juan, HAO Jun-Fang Journal of International Oncology

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Brief introduction of response evaluation criteria in solid tumors Zhang Baihong, Yue Hongyun Journal of International Oncology 2016, 43 (11): 845-847. DOI:10.3760/cma.j.issn.1673-422X.2016.11.011 Abstract（ 792） PDF（pc）（697KB）（ 3743） Knowledge map Save With the coming era of targeted therapy, novel criteria such as the modified response evaluation criteria in solid tumors (RECIST), positron emission tomography response criteria in solid tumors (PETRCIST), Choi criteria and immunerelated response criteria have been proposed as standardized methods to assess therapeutic response. Biomarkers and circulating tumor cells may be considered suitable for the evaluation of response. These criteria may be useful for the evaluation of therapeutic response to tumors. Reference|Related Articles|Metrics|Comments（0）

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XU Xiao-Wei, MENG Xiang-Jun, WANG Chun Journal of International Oncology 2011, 38 (8): 585-588. Abstract（ 527） PDF（pc）（420KB）（ 3738） Knowledge map Save Related Articles|Metrics|Comments（0）

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FENG Wei-Hong, ZHANG Bin, CAO Xu-Chen Journal of International Oncology

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GU Bin, CHEN Jian-Zhong, ZHANG Xin Journal of International Oncology