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Please wait a minute... For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails Select Bone morphogenetic proteins and tumors MI Dong, ZHANG Yue-Xiang, CHEN Shu-Qin, QI Pei Journal of International Oncology 2013, 40 (5): 323-325. Abstract（ 588） PDF（pc）（788KB）（ 1076） Knowledge map Save Bone morphogenetic proteins are multi-functional growth factors, they are found not only inducer of new bone formation, but also have critical roles in cell growth, differentiation, migration, apoptosis, embryogenesis and organogenesis. Studies show that BMPs are closely related to tumorigenesis and metastasis, which indicate that BMPs have important practical values in tumour therapy. Related Articles|Metrics|Comments（0） Cited: Baidu( 4) Select Risk of cancer other than breast or ovarian in Chinese Han women with BRCA1/2 mutations LIU Jing, ZHANG Juan, 欧Yang-Tao , LI Jin-Feng, WANG Tian-Feng, FAN Zhao-Qing, FAN Tie, LIN Ben-Yao, JIE Yun-Tao Journal of International Oncology 2013, 40 (5): 389-392. Abstract（ 572） PDF（pc）（780KB）（ 1826） Knowledge map Save Objective To investigate the risk of cancer other than breast or ovarian in Chinese Han women with family breast cancer who carried a BRCA1 or BRCA2 mutation. Methods Germline mutations in BRCA1/2 genes in the cohort of 465 Chinese Han patients with familial breast cancer were screened using a PCR-sequencing assay. The proportion of cancer other than breast or ovarian was compared in mutantion group and non mutation group. Results Among the 465 familial breast cancer patients, 47 (10.1%) were BRCA1/2 mutation carriers and 418 (89.9%) were non-carriers. There was no significant difference in the total proportion of cancers other than breast or ovarian in the family between BRCA1/2 mutation carriers and non-carriers (27.7% vs29.9%, χ2=0.10, P=0.75). But the tumor spectrum was different between the BRCA1/2 carriers and non-carriers. In the family of BRCA1/2 carriers, the most common cancers were gastric cancer, pancreatic cancer, and prostate cancer; while in the non-carriers, the most common cancers were lung cancer, gastric cancer, and esophageal cancer. The relative risk of gastric cancer, pancreatic cancer and prostate cancer was significantly higher in the families of BRCA1/2 mutation carriers than that of non-carriers (17% vs7.7%, odd ratio: 2.47, 95%CI: 1.07 to 5.74, P=0.048). Conclusion This study suggests that the relative risk of gastric cancer, pancreatic cancer and prostate cancer in BRCA1/2 carriers is moderate higher than in non-carriers in Chinese Han women. Related Articles|Metrics|Comments（0） Cited: Baidu( 1)