Abstract:In eukaryotes, the cell’s material exchangehas long existed inits proliferation and apoptosis, while the exchange of nucleus and cytoplasm only through the shuttle movement of the nuclear pore complex (NPC). NPC in the nuclear membrane, achieves the protein, RNA and other substances’s transport task through the shuttle movement between nucleus and cytoplasm of eukaryotes. Specific nuclear pore proteins regulate specific transport path, and because of this, the transport and regulation through the NPC is highly selective and coordination, so the NPC play an important role in gene expression, cell signaling networks and maintain the environment. Some of them will change the structure properties of membrane, affecting mitosis, and some can be combined with thekinaseleading to abnormal biochemical reactions, or combined with other biological factors in angiogenesis, cell migration or apoptosis of cells leading to abnormal changes, and leading to tumorigenesis.