Journal of International Oncology

Journal of International Oncology››2012,Vol. 39››Issue (2): 92-95.

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Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer

HUANG Fan, LI Yuan, PENG Ming-Qing

  1. Central Laboratory,YongchuanHospital,Chongqing Medical University,Chongqing402160,China
  • Online:2012-02-08Published:2012-01-18
  • Contact:Corresponding author: LI Yuan, E-mail: liyuan_1985999@163.com E-mail:liyuan_1985999@163.com

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Abstract:Expression and regulation of the P-glycoprotein (P-gp)is associated withthe development of multidrug resistance in cancer. Cancer cellsare exposed inendogenous damages from its own micro-environments andinflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would haveimportant significancefor exploring the multidrug resistance of cancer cell.

Key words:font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">Neoplasms,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">P-glycoprotein,Drug resistance,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">Signal transduction