Abstract:High mobility group box-1 (HMGB1) is a nonhistone nuclear protein. Normally, as one component of the chromatin, HMGB1 regulate life activities such as genetic transcription, recombination and gene repair. HMGB1 can be realeased to the outside of the cell, which can be bound up with cells multiplication, differentiation, migration and the growth of nerve axon. Studies show that HMGB1 is correlated with tumor’s occurrence, development, invasion and metastasis, such as lung cancer, colorectal cancer, pancreatic cancer and so on. The studies about the relativity between HMGB1 and gastric cancer play an important role in the diagnosis and treatment of gastric cancers.

Key words:Gastric neoplasms,Immunohisto-chemistry,High mobility group box B1