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08 March 2012, Volume 39 Issue 3 Previous IssueNext Issue

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Advances of tumor-associated fibroblasts in carcinogenesis WANG Hong-Mei, XU Jun-Fa 2012, 39 (3): 163-166. Abstract( 901) PDF(701KB) ( 2511) Save Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor. Tumor-associated fibroblasts(TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors. Related Articles|Metrics

Function and advance of GPR30 in hormone-related neoplasms CAI Ling-Yu, HE Yin-Yan, XI Xiao-Wei 2012, 39 (3): 166-169. Abstract( 810) PDF(701KB) ( 1922) Save G protein-coupled receptor 30 (GPR30), a sort of novel functional estrogen transmembrane receptor, extensively participate in the pathological and physiological regulation by mediating the rapid non-genomic effects of the estrogen, which plays an important role in the occurrence and development of the hormone-related malignant neoplasms. Related Articles|Metrics

Aminopeptidase N and its inhibitors and carcinoma PEI Ke-Ling, ZHANG Hou-Li, CUI Shu-Xiang 2012, 39 (3): 169-171. Abstract( 1473) PDF(714KB) ( 2081) Save Aminopeptidase N, a zinc-dependent exopeptidase, is highly expressed in many kinds of tumors, which involves in the degradation of extracellular matrix barriers and angiogenesis and promotes the invasion and metastasis of cancer cells. Aminopeptidase N inhibitors can induce apoptosis and inhibit the invasion and metastasis of tumor cells, which has become an attractive targetfor anti-tumor therapy. Related Articles|Metrics

Advance of the targeted anti-tumor drugs with small molecule compounds ZHENG Jun, FAN Song-Qing 2012, 39 (3): 172-175. Abstract( 1061) PDF(698KB) ( 3056) Save Small molecule compounds have distinct effects in the targeted anti-tumor field, which can kill tumor cells efficiently and selectively, reduce normal tissue damage, and especially can overcome the poor specificity and serious adverse reaction of the traditional chemotherapy drugs. So small molecule compounds play an important role in recent clinical therapy. Related Articles|Metrics

Function of securin and its research advances in tumor GUO Hong-Yan, JIN Hui-Qin, ZHANG Yun-Fei, ZHANG Xu 2012, 39 (3): 176-179. Abstract( 875) PDF(701KB) ( 2144) Save Securin is a multifunctional protein which is encoded by pituitary tumor-transforming gene. In the metaphase to anaphase transition during mitosis, securin is involved in sister chromatid separation. The aberrant expression of securin is found in many endocrine glands and related cancers, such as pituitary tomour, thyroid cancer, ovarian cancer, colon cancer and so on. The function of securin in cancer is related to its gene transactivation and association with other poteins like p21, p53. Related Articles|Metrics

Mechanism of polarity proteins regulate tumorigenesis ZHAO Wei, LI Xia, YUE Shu-Qiang, DOU Ke-Feng 2012, 39 (3): 179-182. Abstract( 860) PDF(699KB) ( 2626) Save Epithelial architecture is formed intissues and organs when groups of epithelial cells are organized into polarized structures. The epithelial function as well as signaling across the epithelial layer is organized by polarity proteins. Epithelial polarity complexes form and regulate epithelial integrity. Polarity proteins establish and maintain cell polarity, regulate tight junctions and adherens junctions. Polarity proteins act as neoplasms suppressors in mammals and interact with oncogenes, disrupt cell polarity, induce tumorigenesis. Therefore, polarity mechanisms of epithelial cell could provid therapeutic targets for clinical therapy. Related Articles|Metrics

EZH2 gene and cancer BAI Jie, SHUAI Xiao-Ming, TAO Kai-Xiong 2012, 39 (3): 182-186. Abstract( 1413) PDF(710KB) ( 3252) Save EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2), which represses gene expression by catalyzinglysine 27 of histone H3. It is overexpressed in prostate cancer, breast cancer, bladder cancer, gastric cancer and several other cancers.There is a close correlation between overexpression of EZH2 and progression of malignancy, invasion and migration of cancer cells. With a thorough understanding of the function, up and down stream regulatory mechanism and clinicopathological features, EZH2 will be expected to as a target and provide a new way for the treatment of cancers. Related Articles|Metrics

Gene targeting diagnosis and treatment in cancer ZHENG Ya-Bing, WANG Lin, CHANG Xiao-Tian 2012, 39 (3): 186-189. Abstract( 697) PDF(702KB) ( 2319) Save With the development and clinical use of the molecular targeted drugs and individualized treatment, cancer research has been focused on gene targeting diagnosis and treatment. Especially for the epidermal growth factor receptor (EGFR) signaling pathway-related genes, DNA replication-related genes, spindle apparatus format-related genes, cell metabolism-related genes and other molecular targeted detection and treatment, the polymorphism of targeting genes/molecules determines the clinical efficiency of the therapies. Related Articles|Metrics

Antiangiogenic therapy for PTCL WAN Shan, GU Kang-Sheng 2012, 39 (3): 190-193. Abstract( 757) PDF(700KB) ( 1812) Save Peripheral T-cell lymphomas (PTCLs) are insensitive to traditional chemotherapies, and are lack of effective treatments and have worse prognosisthan B-cell lymphomas . Angiogenesis plays an essential role in the malignant tumor growth. Recently, studies have shown that the expression level of VEGF is related to the clinical characteristic and prognosis of PTCL. Novel drugs based on anti-angiogenic theory show curative effect in the preliminary clinical trials for the treatment of PTCL. Related Articles|Metrics

Application of nanoparticle vectors in photodynamic therapy of tumors SHI Lei, WANG Xiu-Li, WANG Hong-Wei 2012, 39 (3): 193-196. Abstract( 785) PDF(701KB) ( 2826) Save For the past few years, with the extensive application of nanoparticle technology in photodynamic therapy (PDT) of cancers, there have been some improvements of the stability of photosensitizers, the tumor targeting, the working depthand the yield of singlet oxygen by a variety of ways. Furthermore, with nanoparticle, PDT also can be combined with some other treatments together. Finally, the use of nanoparticle vectors for PDT is a novel and promising approach which might improve the efficiency of photodynamic therapy for tumors, overcome many adverse effectsand increase the indications of PDT. Related Articles|Metrics

Radiosensitizing effect of natural active product on tumor WANG Juan, JIN Wen-Sen 2012, 39 (3): 196-200. Abstract( 791) PDF(714KB) ( 1725) Save It has been indicated that there are a large number of natural active compounds generating the radiosensitizing effect on tumor. According to diverse molecular mechanism, these compoundsmay enhance the radiotherapeutic efficacy via enhancing the radiosensitivity of tumor. Studying the radiosensitization mechanism and classifying the natural compounds with the potentiality of development into clinical radiosensitizers can provide certain ideas for further research and development of natural radiosensitizers. Related Articles|Metrics

Epidermal growth factor receptor Ⅲ variant and targeted therapy of glioblastoma YAN Hong-Lian, ZHANG Long-Zhen 2012, 39 (3): 200-202. Abstract( 805) PDF(697KB) ( 2196) Save Epidermal growth factor receptor Ⅲ variant (EGFRvⅢ) is high expressed in gliomas, which can be used as a target to treat cancer. The therapy methods of glioblastoma targeted for EGFRvⅢ include RNA interference, immunotherapy, etc. Related Articles|Metrics

Variety of molecular mechanisms of cisplatin in the treatment of nasopharyngeal carcinoma YANG Zhang-Ru, WU Jing-Bo 2012, 39 (3): 203-205. Abstract( 791) PDF(693KB) ( 1921) Save Cisplatin has good effects in the treatment of a variety of solid cancers. Studies have shown that cisplatin can make great contributions in treatment of nasopharyngeal carcinoma through DNA, telomeres, cell cycle, apoptosis, apoptotic volume decrease, cell senescence, NK cells and other channels. Related Articles|Metrics

BRAFV600Egene mutation and papillary thyroid cancer JIAO Xiao-Ping, WANG Sheng-Ying 2012, 39 (3): 206-208. Abstract( 1525) PDF(697KB) ( 2119) Save The BRAF V600Emutation in papillary thyroid carcinoma is the most common genetic event, which is an invasive tumor clinical phenotype and a poor prognosis indicator. The BRAF V600Emutation detection has an important guiding significance for the differential diagnosis of malignant thyroid nodules on preoperative, guiding the surgical resection range of thyroid cancer, judging the patient’s prognosis and guiding the subsequent treatment of postoperative Related Articles|Metrics

Therapy of triple negative breast cancer XU Shuai, ZHANG Xi-Ping 2012, 39 (3): 209-211. Abstract( 826) PDF(693KB) ( 2325) Save Triple negative breast cancer ( TNBC) has its own exclusive pathological and molecular biological characteristic．At present, the treatment guidelines for triple negative breast cancer is not perfect, and the chemotherapy is the main method. A deeper insight into the targeted therapy of TNBC can improve the curative effect Related Articles|Metrics

EML4-ALK fusion gene in non-small-cell lung cancer HUANG Xiao-Lin, CAO Zi-Ang 2012, 39 (3): 212-214. Abstract( 1112) PDF(694KB) ( 2209) Save EML4-ALK fusion gene can improve the expression of anaplastic lymphoma kinase (ALK) protein and activate ALK inducing tumor cells’ proliferation and anti-apoptosis. EML4-ALK fusion gene in non-small-cell lung cancer which has unique clinical and pathological features is more common in young femal, never smokers, and adenocarcinoma patients, At present, EML4-ALK fusion gene can be detected using RT-PCR, FISH and IHC. Crizotinib, an ALK inhibitor, block the gene’s signal pathway and restrain tumor’s activity. Related Articles|Metrics

Different fractionations of radiotherapy in non-small cell lung cancer LI Jing, SONG Yu-Zhi, QIAO Xue-Ying 2012, 39 (3): 215-217. Abstract( 797) PDF(694KB) ( 1979) Save Radiotherapyis an importment local treatment for non-small cell lung cancer. In recent years, with the development of molecular biology and radiotherapy technique and the update of equipment, radiation pattern with different doses segmentation and the concept of the combined therapy including radiotherapy and chemotherapy have been applied inclinic gradually, which get better effects. Related Articles|Metrics

Application of epidermal growth factor receptor for radiotherapy of esophageal cancer ZHANG He-Ping, LI Jian-Cheng 2012, 39 (3): 218-220. Abstract( 803) PDF(693KB) ( 1604) Save Epidermal growth factor receptor (EGFR) express highly or mutant in esophageal cancer, which causing tumor resistance to radiotherapy and leading to poor radiotherapeutic effects. Treatment with anti-EGFR can get radiosensitization. There are three main types of molecular targeted research for EGFR: synthetic monoclonal antibody, small molecule tyrosine kinase inhibitors, and other strategies modulating EGFR biosynthesis based on RNA interference. Related Articles|Metrics

HMGB1 and gastric cancer YUAN Hai-Bin, WANG Dong-Xu, CHEN Xiao-Qing 2012, 39 (3): 220-222. Abstract( 700) PDF(694KB) ( 1535) Save High mobility group box-1 (HMGB1) is a nonhistone nuclear protein. Normally, as one component of the chromatin, HMGB1 regulate life activities such as genetic transcription, recombination and gene repair. HMGB1 can be realeased to the outside of the cell, which can be bound up with cells multiplication, differentiation, migration and the growth of nerve axon. Studies show that HMGB1 is correlated with tumor’s occurrence, development, invasion and metastasis, such as lung cancer, colorectal cancer, pancreatic cancer and so on. The studies about the relativity between HMGB1 and gastric cancer play an important role in the diagnosis and treatment of gastric cancers. Related Articles|Metrics

Mammalian target of rapamycin in gastric cancer CHEN Xiao-Qing, WANG Dong-Xu, YUAN Hai-Bin 2012, 39 (3): 222-224. Abstract( 798) Save Mammalian target of rapamycin (mTOR) plays an important role in the regulation of cell proliferation, growth, energy metabolism and so on. Clinical research demonstrate that many tumors have its excessive expression, and the mTOR inhibitors rapamycin can resist the development of gastric cancer. In recent years, research of mTOR signaling pathway combined with its upstream and downstream has larger value for the early diagnosis, monitoring curative effect and prognosis. Related Articles|Metrics

Treatment of hepatocellular carcinoma withportal vein tumor thrombus LI Feng-E, GUO Zhi 2012, 39 (3): 225-227. Abstract( 744) Save Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is one of the difficult points of liver cancer treatment. At present, there are various clinical treatments of HCC with PVTT which have great significance to lengthen the survival time of patients with liver cancer and improve the quality of life. Surgical therapy and interventional treatment play important roles in the treatments of HCC with PVTT. Related Articles|Metrics

Helicobacter pylori andcolorectal cancer LIANG Yun-Jia, CHU Yu-De, DAI De-Jian 2012, 39 (3): 228-230. Abstract( 786) Save Recent researches of the associationbetween helicobacter pylori (Hp) and colorectal adenocarcinoma have found that Hp infection rate is higher in the patients with colorectal cancerand other related colorectal adenoma, which suggest that Hp probably influence on local and distant intestinal mucosa epithelial cells achieve carcinogenesis by its own virulence and the role of elevated serum gastrin levels. Hp infection may be a potential risk factor of colorectal cancer. Related Articles|Metrics

Progress of the angiogenesis correlation factors for endometrial carcinoma YAN Chun-Xiao, SHENG Xiu-Gui 2012, 39 (3): 230-233. Abstract( 776) Save Angiogenesis is closely related to the occurrence, development, invasion and metastasis of endometrial carcinoma. In recent years, a large number of researches on the angiogenesis correlation factors for endometrial carcinoma have been carried out It is shown that endometrial carcinoma angiogenesis is a complex process with many factors involved in. Related Articles|Metrics

Molecular mechanism ofcisplatin resistance in ovarian cancer HAN Xue-Chuan, FAN Yang 2012, 39 (3): 234-236. Abstract( 755) PDF(693KB) ( 1949) Save Chemotherapy resistance is a great obstacle for effective treatment of ovarian cancer. Drug resistanceof ovarian cancer is the results ofcombined action of multi- factors. Further study of drug resistance-related genes can provide new ideas for reversing drug resistance fundamentally. Related Articles|Metrics

Diagnostic application value of urothelial carcinoma of the urinary bladder by dual color fluorescence in-situ hybridization ZHANG Yu, NI Ze-称, HU Lan-Ting, ZHANG Ning, WANG Qing 2012, 39 (3): 237-240. Abstract( 745) PDF(703KB) ( 1668) Save Objective To evaluate the clinical application value of dual color fluorescence in-situ hybridization (FISH) in detectingurothelial carcinoma of the urinary bladder. Methods The probes of chromosome 3, 7, 17centromeres and chromosome 9p21 region (p16) were labeled by random primer method. FISH was performed on interphase nuclei of 80 urine specimens of cancer of the urinary bladder and 20 cases of healthy persons served as normal controls. Thresholdvalue was established. The pathological diagnosis was the “golden standard”. Chromosome aberration was counted. The correlations between chromosome aberration and pathologic grading and staging and their sensibilityof diagnosis for urothelial carcinoma of the urinary bladder were analyzed. Results The rate of numerical aberration of chromosome 3, 7, 17, 9p21 was 47.5%(38/80), 60.7%(49/80), 51.3%(41/80) and 58.8%(47/80) respectively. The positive rate of the combined use of 3, 7, 17 and 9p21 chromosome probes for detecting urothelial carcinoma of urinary bladder was 76.3%(61/80). The aberrations had no correlation to tumor stage. The aberration of chromosome 3, 7 and 17 were correlated topathologic grade significantly (P﹤0.05). Conclusion The progression of urothelial carcinoma of the urinary bladder is related to the aberrations of chromosome. FISH is believed to be a very important method in diagnosis of urothelial carcinoma of the urinary bladder, which may have important clinical significance for the postoperative recurrence detection and prognosis. Related Articles|Metrics