Abstract:Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor.Tumor-associated fibroblasts(TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors.

Key words:color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Angiogenesis inhibitors,color: black,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: HE,mso-fareast-font-family: 宋体">Tumor-associated fibroblast