Abstract:Allogeneic stem cell transplantation is the only treatment which may cure multiple myeloma (MM). The high transplantation related mortality (TRM) limits the wide clinical application of myeloablative allogeneic stem cell transplantation. Non-myeloablative allogeneic stem cell transplantation can reduce the TRM, but the risk of relapse and progress of the disease may get increased. Auto- nonmyeloablative allogeneic stem cell tandem transplantation can reduce both the TRM and the relapse and progress of the disease. At present, there exist many new methods which may improve the effect of allogeneic stem cell transplantation for MM in clinical.

Key words:Multiple myeloma,Stem cell transplantation,Therapeutics