Abstract:As the main drug in colorectal cancer chemotherapy, oxaliplatin is gradually infiltrated into other malignancies therapy. But oxaliplatininduced peripheral neuropathy limits its clinical application. The mechanisms of oxaliplatin neurotoxicity are not yet clear. Recent researches show that the acute neurotoxicity of oxaliplatin is mediated through changes in Na+ transient conductances. And the function of the mitogenactivated protein kinases in chronic neuropathy has already been demonstrated in vitro. Furthermore, numerous indicators can be used to predict oxaliplatininduced peripheral neuropathy, which bring the hope for improving the continuity of chemotherapy and realizing personalized medicine therapy.

Key words:Oxaliplatin,Neurotoxins,Tumor markers, biological