Abstract:In the complex set of biological processes that a particular malignancy to metastasize, tumor cells must adapt to different survival pressures. As an important cellphysiologic response that under regulation of many genes and their expressions, autophagy not only can be strongly induced to adapt to metabolic stresses and microenvironmental changes, but also involved in the process of epithelialmesenchymal transition (EMT), restricting inflammation, resisting anoikis, maintaining dormancy in the metastatic process.

Key words:Autophagy,Neoplasm metastasis