Journal of International Oncology››2013,Vol. 40››Issue (12): 889-892.doi:10.3760/cma.j.issn.1673-422X.2013.12.003

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Mechanisms and reversal strategies of tumor multidrug resistance

WU Jing, YANG Rui, LIU Shu-Ye

  1. Department of Clinical Laboratory, Tianjin Third Central Hospital, Tianjin 300170, China
  • Online:2013-12-10Published:2013-12-26
  • Contact:LIU Shu-Ye E-mail:lshye@163.com

Abstract:Tumor multidrug resistance (MDR) is the leading cause of clinical chemotherapy failure and death. Researches show that the occurrence of MDR is related to Pglycoprotein, multidrug resistanceassociated proteins, breast cancer resistanceassociated proteins, lung resistancerelated proteins and other factors. Now the reversal strategies of MDR include chemical drugs reversal, gene reversal, immune reversal, traditional Chinese medicine reversal and drugloaded nanosystem reversal, which make some progress and help to improve the effect of cancer chemotherapy.

Key words:Neoplasms,Drug resistance, multiple,Nanotechnology