Journal of International Oncology››2013,Vol. 40››Issue (7): 483-485.

Next Articles

Mast cells and tumor angiogenesis

CAO Li, LI Wei, DENG Fan-

  1. Department of Cell Biology, Southern Medical University, Guangzhou 510515, China
  • Online:2013-07-08Published:2013-07-08
  • Contact:DENG Fan E-mail:fandeng@smu.edu.cn

Abstract:Mast cells (MCs) are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor-derived stem cell fact MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can or (SCF) and its receptor c-kit on MCs. Neovascularization is necessary for the tumor growth by providing plenty of nutrients and oxygen. The numbers and distributions of mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors.

Key words:Mast cells,Neoplasms,Neovascularization, pathologic