Journal of International Oncology››2013,Vol. 40››Issue (8): 605-607.

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Tumor necrosis factor-related apoptosis inducing ligand and its receptorsin hepatocellular carcinoma

XU Jian, LI Jing-Dong

  1. Department of General Surgery, Institute ofHepatobiliary-Pancreatic-Intestinal Diseases,Affiliated Hospital of North Sichuan Medical College, Nanchong 637000,China
  • Online:2013-08-08Published:2013-08-15
  • Contact:Corresponding author:LI Jing-dong, E-mail: lijingdong358@126.com E-mail: lijingdong358@126.com

Abstract:Tumor necrosis factor-related apoptosis inducing ligands (TRAIL) and its receptors can specifically express inhepatocellular carcinomacells. TRAIL can specifically induce tumor cells apoptosis through death receptors (DRs); TRAIL combined radiation and chemotherapy can effectively overcome the TRAIL resistance of tumor cells, and promote the apoptosis of tumor cells, meanwhile the gene therapy of TRAIL on anti-tumor clinical treatment has been widely used.

Key words:TNF-related apoptosis-inducing ligand,Receptors, TNF-related apoptosis-inducing ligand,Liver neoplasms