Journal of International Oncology››2014,Vol. 41››Issue (1): 31-34.doi:10.3760/cma.j.issn.1673-422X.2014.01.010

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Tumor angiogenesis in esophageal cancer

Wang Wei, Hu Bing, He Yifu

  1. Department of Medical Oncology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China
  • Online:2014-01-08Published:2014-01-22
  • Contact:Hu Bing E-mail:hubing2013oncol@gmail.com

Abstract:High invasive potential of esophageal carcinoma is often associated with angiogenesis, accompanied by the changes of microvessel density, vascular endothelial growth factor, angiogenic factors and their receptors. Studies show that there are significant correlations between increased serum levels of angiogenic factors and insufficient treatment response and poor prognosis in patients with esophageal cancer. Such angiogenesisrelated molecules may represent novel targets in treating esophageal cancer, which deserve further exploration.

Key words:Esophageal neoplasms,Neovascularization, pathologic,Vascular endothelial growth factors,Targeted therapy