Abstract:As a way of gene modification, alternative splicing is an important factor of eukaryotic gene expression and regulation. It makes various transcripts from one proteincoding gene, and greatly extends the genetic information. Alternative splicing of premessenger RNA plays an important role in tumor cells. By alternative splicing, some important genes can generate splicing variants different from those in normal cells. The existence of tumorspecific splicing variants leads to the occurrence and progression of tumor. Therefore, exploration on the alternative splicing of tumorassociated genes may be of great significance in tumor diagnosis and treatment.

Key words:Neoplasms,RNA, messenger,Alternative splicing