Journal of International Oncology››2016,Vol. 43››Issue (5): 382-384.doi:10.3760/cma.j.issn.1673-422X.2016.05.016

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Research progress of CTHRC1 in gastrointestinal cancers

Wang Yan, Wang Lu, Feng Jiangzhou, Li Deng

  1. Department of Medical Oncology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, China
  • Online:2016-05-08Published:2016-04-07
  • Contact:Wang Lu E-mail:lucyyjs@163.com

Abstract:Collagen triple helix repeat containing 1 (CTHRC1) can repair the injured vessel by limiting the deposition of collagen and promoting cell migration. CTHRC1 is mainly regulated by WntPCP signaling pathway, transforming growth factor (TGF)bone morphogenetic protein (BMP) signaling pathway and extracellular signalregulated kinase (ERK)matrix metalloproteinase 9 (MMP9) signaling pathway. Recent studies have identified that CTHRC1 is aberrantly expressed in gastrointestinal cancers and associated with the occurring and development of cancers.

Key words:Digestive system neoplasms,Genes,Collagen triple helix repeat containing 1