Journal of International Oncology

Journal of International Oncology››2017,Vol. 44››Issue (12): 914-917.doi:10.3760/cma.j.issn.1673-422X.2017.12.008

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Interferon alpha-inducible protein 27 and tumor

Liu Honglu, Liu Xin, Chen Yan, Li Ping, Wang Xicai

  1. Tumor Research Institute of Third Affiliated Hospital of Kunming Medical University ＆ Yunnan Tumor Hospital, Kunming 650118, China
  • Online:2017-12-08Published:2017-12-01
  • Contact:Wang Xicai, Email: wangxc2005323@126.com E-mail: wangxc2005323@126.com
  • Supported by:
    National Natural Science Foundation of China (81460358); Applied and Basic Research Foundation of Yunnan Provincial Science and Technology Department-Kunming Medical University (2014FB066); Project of Medical and Health Technology Development Program of Yunnan Province of China (2014NS023, 2014NS024); Zhan Qimin Academician Workstation Project of Yunnan Province of China (2015IC002)

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Abstract:Interferon alpha-inducible protein 27 (IFI27) is a newly discovered protein that participates in biological functions such as apoptosis, cell autophagy, oncolytic and immunoregulation. It also plays a major role in promoting tumor development, such as in breast cancer, ovarian cancer, liver cancer, squamous cell carcinoma and so on. Besides, studies have shown that IFI27 can interact with signal transducer and activator of transcription 1, microRNAs, interferon regulatory factor 4 and other genes, which promotes the development of tumors. Therefore, IFI27 is expected to be a marker for the occurrence and development of tumors, providing a new target for cancer therapy.

Key words:Apoptosis,Neoplasms,Interferon alpha-inducible protein 27