Journal of International Oncology››2023,Vol. 50››Issue (1): 51-54.doi:10.3760/cma.j.cn371439-20221005-00010

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Study progression on mechanism of long non-coding RNAs regulating drug resistance in osteosarcoma

Ma Xiaoping, Chang Junli, Sun Xingyuan, Yang Yanping()

  1. Spine Disease Research Institute, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai 200032, China
  • Received:2022-10-05Revised:2022-11-06Online:2023-01-08Published:2023-03-16
  • Contact:Yang Yanping E-mail:yanpingyang@shutcm.edu.cn
  • Supported by:
    National Key Research and Development Program of China(2018YFC1704300);National Key Research and Development Program of China(2020YFE0201600);National Natural Science Foundation of China(81973877);National Natural Science Foundation of China(82174408)

Abstract:

Osteosarcoma is the most common primary solid bone malignancy. The main factor leading to recurrence and metastasis of osteosarcoma is resistance to chemotherapy drugs. Long non-coding RNAs can affect drug resistance in osteosarcoma by regulating epithelial-mesenchymal transition, cell autophagy, apoptosis, drug efflux, and cell cycle, suggesting that long non-coding RNAs may become new targets for drug resistance in osteosarcoma treatment.

Key words:RNA, long non-coding,Osteosarcoma,Drug resistance, neoplasms