Journal of International Oncology››2023,Vol. 50››Issue (8): 489-492.doi:10.3760/cma.j.cn371439-20230308-00093

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Mechanism of action and clinical significance of CST1 in the progression of gastric cancer

Shao Huifang1, Wang Xuehong2, Lu Yongfu2()

  1. 1Graduate School of Qinghai University, Xining 810016, China
    2Department of Gastroenterology, Affiliated Hospital of Qinghai University, Xining 810001, China
  • Received:2023-03-08Revised:2023-03-25Online:2023-08-08Published:2023-10-24
  • Contact:Lu Yongfu E-mail:gyxb123@163.com
  • Supported by:
    Hospital-Level Key Discipline Construction Project of the Affiliated Hospital of Qinghai University(〔2019〕195)

Abstract:

Cysteine protease inhibitor 1 (CST1) is a member of type 2 Cystatins superfamily, plays a key role in targeted regulation. CST1 is highly expressed in gastric cancer, promotes tumor cell migration and invasion by activating the epithelial-mesenchymal transformation pathway and Wnt pathway, and regulates tumor growth and progression in combination with the corresponding target genes of homeobox C10 and glutathione peroxidase 4. A deeper understanding of the role and function of CST1 in gastric cancer will help to further develop potential therapeutic targets and diagnostic and prognostic markers for gastric cancer.

Key words:Stomach neoplasms,Cysteine protease inhibitor 1