Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment

Abstract

Wang Wei, Yang Xuejun. Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment[J]. Journal of International Oncology, 2017, 44(3): 205-208.

［1］ Parks SK, Chiche J, Pouysségur J. Disrupting proton dynamics and energy metabolism for cancer therapy［J］. Nat Rev Cancer, 2013, 13(9): 611 -623. DOI: 10.1038/nrc3579. ［2］ Webb BA, Chimenti M, Jacobson MP, et al. Dysregulated pH: a perfect storm for cancer progression［J］. Nat Rev Cancer, 2011, 11(9): 671-677. DOI: 10.1038/nrc3110. ［3］ Cong D, Zhu W, Kuo JS, et al. Ion transporters in brain tumors［J］. Curr Med Chem, 2015, 22(10): 1171-1181. ［4］ Parker MD, Myers EJ, Schelling JR. Na+H+ exchanger1 (NHE1) regulation in kidney proximal tubule［J］. Cell Mol Life Sci, 2015, 72(11): 2061-2074. DOI: 10.1007/s0001801518488. ［5］ Amith SR, Fliegel L. Regulation of the Na+/H+ exchanger (NHE1) in breast cancer metastasis［J］. Cancer Res, 2013, 73(4): 1259-1264. DOI: 10.1158/00085472.CAN124031. ［6］ Xu J, Ji B, Wen G, et al. Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin 6mediated cellular behavior of human hepatocellular carcinoma［J］. Carcinogenesis, 2016, 37(3): 290 -300. DOI: 10.1093/carcin/bgw004. ［7］ Matsushita M, Tanaka H, Mitsui K, et al. Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1［J］. Am J Physiol Cell Physiol, 2011, 301(2): C280-288. DOI: 10.1152/ajpcell.00404.2010. ［8］ Vargas LA, Díaz RG, Swenson ER, et al. Inhibition of carbonic anhydrase prevents the Na(+)/H(+) exchanger 1dependent slow force response to rat myocardial stretch［J］. Am J Physiol Heart Circ Physiol, 2013, 305(2): H228-237. DOI: 10.1152/ajpheart.00055.2013. ［9］ Beaty BT, Wang Y, BravoCordero JJ, et al. Talin regulates moesinNHE1 recruitment to invadopodia and promotes mammary tumor metastasis［J］. J Cell Biol, 2014, 205(5): 737-751. DOI: 10.1083/jcb.201312046. ［10］ Fuster DG, Alexander RT. Traditional and emerging roles for the SLC9 Na+/H+ exchangers［J］. Pflugers Arch, 2014, 466(1): 61-76. DOI: 10.1007/s0042401314088. ［11］ Rose KL, Watson AJ, Drysdale TA, et al. Simulated diabetic ketoacidosis therapy in vitro elicits brain cell swelling via sodiumhydrogen exchange and anion transport［J］. Am J Physiol Endocrinol Metab, 2015, 309(4): E370-379. DOI: 10.1152/ajpendo.00107.2015. ［12］ Yi YH, Chang YS, Lin CH, et al. Integrinmediated membrane blebbing is dependent on sodiumproton exchanger 1 and sodiumcalcium exchanger 1 activity［J］. J Biol Chem, 2012, 287(13): 10316-10324. DOI: 10.1074/jbc.M111.244962. ［13］ Chang G, Wang J, Zhang H, et al. CD44 targets Na(+)/H(+) exchanger 1 to mediate MDAMB231 cells′ metastasis via the regulation of ERK1/2［J ］. Br J Cancer, 2014, 110(4): 916-927. DOI: 10.1038/bjc.2013.809. ［14］ McGrail DJ, McAndrews KM, Brandenburg CP, et al. Osmotic regulation is required for cancer cell survival under solid stress［J］. Biophys J, 2015, 109(7): 1334-1337. DOI: 10.1016/j.bpj.2015.07.046. ［15］ Amith SR, Fong S, Baksh S, et al. Na(+)/H(+) exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?［J］. Int J Dev Biol, 2015, 59(79): 367-377. DOI: 10.1387/ijdb.140336lf. ［16］ Liberti MV, Locasale JW. The Warburg Effect: how does it benefit cancer cells?［J］. Trends Biochem Sci, 2016, 41(3): 211-218. DOI: 10.1016/j.tibs.2015.12.001. ［17］ Reshkin SJ, Greco MR, Cardone RA. Role of pHi, and proton transporters in oncogenedriven neoplastic transformation［J］. Philos Trans R Soc Lond B Biol Sci, 2014, 369(1638): 20130100. DOI: 10.1098/rstb.2013.0100. ［18］ Yang X, Wang D, Dong W, et al. Overexpression of Na+/H+ exchanger 1 and its clinicopathologic significance in hepatocellular carcinoma［J］. Med Oncol, 2010, 27(4): 1109-1113. DOI: 10.1007/s1203200993434. ［19］ Xia J, Huang N, Huang H, et al. Voltagegated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1mediated upregulation of NHE1［J］. Int J Cancer, 2016, 139(11): 2553-2569. DOI: 10.1002/ijc.30381. ［20］ Cardone RA, Greco MR, Zeeberg K, et al. A novel NHE1centered signaling cassette drives epidermal growth factor receptordependent pancreatic tumor metastasis and is a target for combination therapy［J］. Neoplasia, 2015, 17(2): 155-166. DOI: 10.1016/j.neo.2014.12.003. ［21］ Zhu W, Carney KE, Pigott VM, et al. Gliomamediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1［J］. Carcinogenesis, 2016, 37(9): 839-851. DOI: 10.1093/carcin/bgw068. ［22］朱蒙, 杨学军. 钙信号在恶性肿瘤侵袭迁移中的作用［J］. 国际肿瘤学杂志, 2014, 41(3): 161-164. DOI: 10.3760/cma.j.issn.1673422X.2014.03.001. ［23］ Lin Y, Chang G, Wang J, et al. NHE1 mediates MDAMB231 cells invasion through the regulation of MT1MMP［J］. Exp Cell Res, 2011, 317 (14): 2031-2040. DOI: 10.1016/j.yexcr.2011.05.026. ［24］ Provost JJ, Rastedt D, Canine J, et al. Urokinase plasminogen activator receptor induced nonsmall cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity［J］ . Cell Oncol (Dordr), 2012, 35（2）： 95-110. DOI: 10.1007/s134020110068y. ［25］ Ludwig FT, Schwab A, Stock C. The Na+/H+ exchanger (NHE1) generates pH nanodomains at focal adhesions［J］. J Cell Physiol, 2013, 228(6): 1351-1358. DOI: 10.1002/jcp.24293. ［26］ Chang F, Minc N. Electrochemical control of cell and tissue polarity ［J］. Annu Rev Cell Dev Biol, 2014, 30: 317-336. DOI: 10.1146/annurevcellbio100913013357. ［27］ Wallert MA, Hammes D, Nguyen T, et al. RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acidinduced transport, cytoskeletal organization and migration［J］. Cell Signal, 2015, 27(3): 498-509. DOI: 10.1016/j.cellsig.2015.01.002. ［28］ Magalhaes MA, Larson DR, Mader CC, et al. Cortactin phosphorylation regulates cell invasion through a pHdependent pathway［ J］. J Cell Biol, 2011, 195(5): 903-920. DOI: 10.1083/jcb.201103045. ［29］ Zhang S, Liu F, Mao X, et al. Elevation of miR27b by HPV16 E7 inhibits PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells［J］. Int J Oncol, 2015, 47(5): 1759-1766. DOI: 10.3892/ijo.2015.3162. ［30］ Lin Y, Wang J, Jin W, et al. NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1MMP［J］. Cell Biochem Funct, 2012, 30(1): 41-46. DOI: 10.1002/cbf.1815. ［31］ Amith SR, Wilkinson JM, Fliegel L. Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelialmesenchymal transition of triplenegative breast cancer cells［J］. Oncotarget, 2016, 7(16): 21091- 21113. DOI: 10.18632/oncotarget.8520. ［32］ Andersen AP, Flinck M, Oernbo EK, et al. Roles of acidextrudingion transporters in regulation of breast cancer cell growth in a 3dimensional microenvironment［J］. Mol Cancer, 2016, 15(1): 45. DOI: 10.1186/s1294301605280. ［33］ Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity［J］. Cell, 2011, 147(5): 992-1009. DOI: 10.1016/j.cell.2011.11.016. ［34］ Thompson EG, Sontheimer H. A role for ion channels in perivascular glioma invasion［J］. Eur Biophys J, 2016, 45(7): 635-648. DOI: 10.1007/s002490161154x.

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Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment

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