Journal of International Oncology››2018,Vol. 45››Issue (12): 751-755.doi:10.3760/cma.j.issn.1673-422X.2018.12.011

Previous ArticlesNext Articles

Predictive biomarkers of efficacy to PD-1/PD-L1 inhibitors

Wang Axiang, Gao Quanli

  1. Department of Biological Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
  • Online:2018-12-08Published:2019-02-01
  • Contact:Gao Quanli E-mail:gaoquanli1@aliyun.com
  • Supported by:

    Henan Medical Science and Technique Foundation (201701030); Henan Provincial Scientific and Technological Project (162300410095)

Abstract:With the development of tumor precise immunotherapy, it is a hot topic to find biomarkers to predict the response ability of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1). So far, many predictors, such as the PD-L1 expression in tumor tissue, tumorinfiltrating lymphocyte, tumor mutational burden, serum markers and radiographic markers, have shown predictive value in the process of antiPD-1/PD-L1 immunotherapy. But each predictor has its limitations.

Key words:Biological markers,Forecasting,PD-1/PD-L1