Journal of International Oncology››2011,Vol. 38››Issue (8): 569-571.

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SIRT1 and neoplasms.

GUO Shu-Qin, ZHU Chun-Ying, ZHANG Yun-Liang

    • Received:2011-04-13Revised:2011-07-03Online:2011-08-08Published:2011-08-29

    Abstract:SIRT1 (Sirtuin type 1) is dependent on nicotinamide adenine dinucleotide (NAD +) group Protein deacetylase involved in the covalent modification of histones, participated in tumor development and progression through transcription, translation and post-translational modification and so on. Therefore, the expression of SIRT1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development,and may become a new potential therapeutic targets for cancer

    Key words:SIRT1,neoplasms,Target therapy