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08 August 2011, Volume 38 Issue 08 Previous IssueNext Issue

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SIRT1 and neoplasms. GUO Shu-Qin, ZHU Chun-Ying, ZHANG Yun-Liang 2011, 38 (8): 569-571. Abstract( 1455) PDF(286KB) ( 2627) Save SIRT1 (Sirtuin type 1) is dependent on nicotinamide adenine dinucleotide (NAD +) group Protein deacetylase involved in the covalent modification of histones, participated in tumor development and progression through transcription, translation and post-translational modification and so on. Therefore， the expression of SIRT1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development，and may become a new potential therapeutic targets for cancer Related Articles|Metrics

Follicle stimulating hormone (FSH) and tumor angiogenesis LIU Tao, REN Jing-Hua, WU Gang 2011, 38 (8): 572-574. Abstract( 1406) PDF(329KB) ( 2012) Save [Abstract] Follicle stimulating hormone (FSH) has been demonstrated to regulate the angiogenesis of ovarian cancer by modulating the expressing of some factors such as hypoxia induce factor-1 （HIF-1）、vascular endothelial growth factor (VEGF). Meanwhile, recently several studies reported that FSH may also impact the angiogenesis of other solid tumors like lung cancer. Thus, in this article we review the relationship between FSH and the angiogenesis process of solid tumors and conclude that FSH- FSHR could become a promising target for anti-angiogenesis therapy through further research. Related Articles|Metrics

Aberrant gap junction and tumor WANG Juan, XIA Juan 2011, 38 (8): 582-584. Abstract( 896) PDF(279KB) ( 2121) Save Gap junctions are membrane structures made of intercellular channels that allow direct exchange of material and information between adjacent cells. It is the structural basis of gap junctional intercellular communication. A lot of data suggest that aberrant gap junction often involves in variety of cancer models, it relatives with tumorgenesis and metastasis. It may provide a novel therapeutic target for tumor treatment when utilize connexin to design new anti-cancer drug. Related Articles|Metrics

Research advance of Dendritic cell vaccines to combat glioma XU Hao, WANG Zhan-Xiang 2011, 38 (8): 596-598. Abstract( 837) PDF(328KB) ( 1986) Save Dendritic cell (DC)-based vaccine therapies represent a novel experimental approach to treat malignant gliomas.Target selection heightens the specificity of vaccine,while engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer enhances the cancer vaccine potency.With the accumulation of clinical experience，it can improve clinical curative effect in the treatment of paitients. Related Articles|Metrics

Mucosal malignant melanoma of the head and neck MAO Xiao-Chun, SHANG Jin-Biao 2011, 38 (8): 599-601. Abstract( 907) PDF(363KB) ( 1855) Save Mucosal malignant melanoma of the head and neck is one of the rarely malignant diseases, The standard therapy for mucosal melanoma of the head and neck continues to be radical surgery, possibly associated with adjuvant radiation. The immunotherapy and chemotherapeutics confirmed existence certain curative effect, Molecular staging and targeted therapy may will be the new tendency in future. Related Articles|Metrics

Advance of radiotherapy in comprehensive therapy for gastric cancer LI Jia, YU Yong-Hua, LIU Xi-Jun 2011, 38 (8): 614-617. Abstract( 670) PDF(301KB) ( 1626) Save Radiotherapy is an effective mean of treatment for gastric cancer, radiotherapy combine with chemotherapy in gastric cancer preoperative，postoperative and palliatie care can improve the local control and survival rate of gastric cancer patients.With the development of 3 dimensional conformal radiation therapy and intensity modulated radiation therapy ,the radiotherapy is being more extensively applicable in the comprehensive treatment of gastic cancer. Related Articles|Metrics

Application of Interstitial implantation of radioactive particles in pancreatic cancer HUANG Ting, WANG Ruo-Yu, LIU Bin 2011, 38 (8): 618-619. Abstract( 783) PDF(350KB) ( 1736) Save Radioactive seed implantation of pancreatic cancer is a very effective treatment, the indications, contraindications and complications has been improved gradually, radioactive particles can be implanted precisely under CT or ultrasound-guided, treatment of particles can be combined with chemotherapy, radiofrequency ablation and other means to improve the clinical efficacy. Related Articles|Metrics

Considerations in rectal cancer after neoadjuvant chemoradiotherapy for wait and see ZHANG Hai-Qin, WANG Ren-Ben 2011, 38 (8): 620-623. Abstract( 880) PDF(305KB) ( 2354) Save Neoadjuvant chemoradiotherapy has been used as a standard treatment for patients with locally advanced (T3 and T4) rectal carcinoma. A proportion of the patients received neoadjuvant chemoradiotherapy present with a pathological complete response (pCR), an entity defined as absence of any tumor cell. In Habr-Gama's reseach, immediate surgery was avoided by for highly selected patients. Those patients who sustained a complete clinical response(cCR) for at least 12months did no worse than those who had surgery over the same period of time with no residual cancer at pathological evaluation.Further researches are still needed to investigate whether it is safe to avoid and just wait and see for highly selected patients. Related Articles|Metrics

Chemotherapy in aggressive T-cell non-Hodgkin lymphoma CHEN Yu, GU Kang-Sheng 2011, 38 (8): 626-629. Abstract( 896) PDF(323KB) ( 1946) Save T-cell non-Hodgkin lymphoma is a group disease with unique clinical and pathological features，compared with B-cell lymphoma，more aggressive， and lower chemotherapy sensitivity．In recent years,to explore high efficiency and light therapy adverse reactions chemotherapy，novel agents(such as gemcitabine ，pralatrexate and so on), targeted therapy combined with chemotherapy and high-dose chemotherapy combined with hematopoietic stem cell transplantation are studied for the treatment,and made some progress． Related Articles|Metrics