Abstract:Basal-like breast cancer (BLBC) is a basal cell phenotype and associated with different levels of expression in basal cell keratin and (or) myoepithelial markers in breast cancer, which has a unique genetic phenotype and morphological characteristics. BLBC is prevalent in young woman, and it is easy to relapse and metastasis. Additionally, most BLBC has expression loss of estrogen receptor and progesterone receptor and human epidermal growth factor receptor 2, which limits the targeted therapeutic options for these predominantly triple-negative breast cancers.

Key words:Breast neoplasms,Molecular pathology,Therapy