Abstract:Hepatocyte growth factor (HGF), a multifunctional cytokine, plays a biological role through acting on the cell surface transmembrane receptor c-Met. The growth, invasion and metastasis of many tumors are associated with the abnormalities of HGFc-Met signaling pathway. Studies found that HGF and its receptor c-Met have close relations with the occurrence, metastasis, invasion and prognosis of multiple myeloma.

Key words:Hepatocyte growth factor,Multiple myeloma