Journal of International Oncology››2012,Vol. 39››Issue (12): 935-938.

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Significance of microsatellite instability in colorectal cancer

ZHI Wen-Xue, SHI Su-Sheng

  1. Department of Pathology,Cancer HospitalInstitute,Chinese Academy of Medical Science,Peking Union Medical College,Beijing 100021,China
  • Online:2012-12-08Published:2012-11-15
  • Contact:Corresponding author:SHI Su-sheng, E-mail: shishusheng@sina.com.cn E-mail:shishusheng@sina.com.cn

Abstract:Microsatellite instability (MSI) is an important molecular mechanism in colorectal cancer’s initiation and progression, which has significant clinical significance. MSI is a diagnostic biomarker for Lynch synchrome. Moreover, the clinical implication of MSI testing extends to the role of prognostic marker and predictive maker, due to the better outcome of patients with MSI positive colorectal cancer and a general lack of response to chemotherapy employing 5-fluorouracil.

Key words:Microsatellite instability,Colorectal neoplasms,Prognosis,Drug therapy