Abstract:mTOR signaling pathway is closely related to cell proliferation, cell cycle and other pathological processes about tumor. Rapamycin plays an antitumor effect through inhibiting mTOR, but it prone to drug resistance, which leads to limited clinical application. Its resistant mechanism is related with the activation of PI3KAkt, which is regulated with negative feedback. Dual inhibitors of related proteins of mTOR pathway are expected to reverse the drug resistance.

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margin-bottom: 0pt,text-indent: 23.52pt,text-align: justify">font-family: '宋体',mso-spacerun: 'yes'">Sirolimus,Drug resistance,mammalian target of rapamycin