ObjectiveThe causal relationship between Anaemias and hypertension in pregnancy remains unclear. Thise article is to examine the causal association between Anaemias and hypertension in pregnancy with two-sample Mendelian randomization analyses.MethodsSummary-level data for anaemias are obtained from the FinnGen consortium （15 153 cases and 393 684 controls）. Summary-level data for hypertension in pregnancy are obtained from the FinnGen consortium （16 417 cases and 213 893 controls）. Inverse-variance weighted analysis， weighted-median analysis， and Mendelian randomization-Egger regression are conducted in this Mendelian randomization analysis. Sensitivity analyses are conducted to confirm the accuracy and robustness of the results.ResultsUsing IVW， it is found that genetically predicted Anaemias is significantly positively associated with hypertension disorders in pregnancy. Genetically determined childhood obesity significantly affects hypertension in pregnancy by IVW （OR= 1.313，95%CI：1.179 - 1.461；P< 0.001） and weighted median （OR= 1.287，95%CI： 1.120 - 1.480；P< 0.001）.ConclusionA causal effect between genetically predicted Anaemias and the risk of hypertension in pregnancy has been identified. The prevention of hypertension in pregnancy should be promoted in populations with Anaemias.
ObjectiveFind the key factors regulating the initiation of protein translation in the process of controlling energy balance in obesity.MethodsThis study analyzes the differentially expressed mRNAs in omental adipose tissue of obese individuals and healthy controls by high-throughput RNA sequencing， and finds abnormal translation initiation levels. The differentially expressed mRNAs are functionally enriched by GO enrichment and KEGG pathway analysis， and further analyzed around the eukaryotic translation initiation family （eukaryotic translation initiation family， eIFs）， and the expression of eIFs in ob/ob mice， db/db mice， primary adipocytes and C3H10T1/2 cell differentiation models is verified by GEPIA/GEO database verification， Western blotting experiments and qPCR.ResultsIn the omental adipose tissue of obese patients， the expression of translation initiation factor 3e （eIF3e） decreases significantly. The GEPIA/GEO database confirms the negative correlation between eIF3e and obesity-related metabolic phenotypes and adipogenesis-related genes. During the induction and differentiation of primary adipocytes and C3H10T1/2 cells in culture， the negative regulatory role of eIF3e in adipogenesis has been discovered. Under β3 adrenergic stimulation， the positive increase of eIF3e accompanied by energy expenditure has been detected in the adaptive thermogenesis mouse model and C3H10T1/2 cells.ConclusioneIF3e is downregulated during adipogenesis and upregulated during lipolysis， suggesting that eIF3e may be a key factor in regulating the initiation of protein translation during the control of energy balance in obesity.
ObjectiveThis study investigated the effect of lung nodule screening in non-high-risk groups of lung cancer in Foshan， hoping to provide a practical basis for early screening and early diagnosis of lung cancer in non-high-risk groups.MethodsFrom January 1， 2023 to September 30， 2024， those in Foshan who underwent physical examination at the physical examination center of Nanhai hospital of Guangdong Provincial people's hospital were screened out through questionnaires in accordance with the standards of the Chinese expert consensus on the diagnosis and treatment of pulmonary nodules （2018 Edition）， and low-dose CT （LDCT） examination of the chest was performed to analyze the detection rate of pulmonary nodules， the relationship between pulmonary nodules and age and gender， and the density， size， and number of pulmonary nodules. For patients with pulmonary nodules， except for those with obvious signs of benign nodules， standardized follow-up was carried out to obtain clinical outcomes.ResultsA total of 2 731 non-high-risk groups for lung cancer were screened， including 1 181 males and 1 550 females. A total of 1 512 cases of pulmonary nodules were detected， with a detection rate of 55.36% （1 512/2 731）， of which the detection rates of males and females were 55.04% and 55.61%， respectively， and the detection rate of pulmonary nodules in the age group of 30 - <40 years was not lower than that of the age group aged 40 years and later， and the detection rate was not related to age， and the difference was not statistically significant （P> 0.05）. A total of 829 cases （30.36%） of solid nodules， 660 cases （24.17%） of pure ground-glass nodules， 23 cases （0.84%） of partial solid nodules， 618 cases （22.63%） of small nodules （diameter 5 ~ 10 mm）， and 25 cases （0.92%） of pulmonary nodules larger than 10 mm were detected. There were 37 cases of highly suspected lung cancer， and 11 cases were diagnosed with pathological diagnosis after follow-up， with a detection rate of 0.40%， including 8 cases of early lung cancer （stage Ι lung cancer）， and the early diagnosis rate was 72.73% （8/11）， all of which occurred in patients under 60 years old， and 2 cases were between 30 and 40 years old. Suspected lung cancer and the detection rate of lung cancer increase with age.ConclusionScreening of lung nodules in non-lung cancer high-risk groups can detect earlier lung cancer and improve the early diagnosis rate of lung cancer. It is recommended that the age of screening for pulmonary nodules be advanced to 30 years， and the follow-up time should be extended in combination with risk factors.
ObjectiveThis article is to analyze the detection results of IgM antibody in suspected measles and rubella cases in Taian from 2014—2023， and provide scientific basis for measles and rubella prevention and control work.MethodsIgM antibody in serum samples of suspected measles and rubella cases sent for testing by disease control centers in various counties and districts of the city is detected by enzyme-linked immunosorbent assay， and the results are statistically analyzed.ResultsFrom 2014—2023， a total of 1861 suspected cases of measles and rubella were detected， and 536 cases were positive for IgM measles antibody with a positive rate of 28.80%. 38 cases were positive for IgM rubella antibody with a positive rate of 2.04%. The ages of onset of measles are mainly 8 ~ 11 months and 30 ~ 39 years old， and the rubella cases concentrated in people aged 7 ~ 18 years old. The peak season of measles was from March to June， Rubella’s peak season was from March to May. Xintai district had the most measles cases； and Ningyang county had the most rubella cases. The main distribution of measles positive cases among different populations is among scattered children， farmers， and workers. The top three positive cases of rubella are students， scattered children， and farmers， respectively. The positive rates of measles IgM antibody were 16.92%， 45.37% and 32.15% in those with immune history， those without immune history and those with unknown immune history， respectively. There was significant difference among the three groups in the positive rate （χ2= 139.766，P< 0.001）.ConclusionThe prevention and control work of measles in Tai’an is stable and effective， which focuses on the routine vaccination and booster immunization for measles and rubella vaccines among children and adults， improving immunization coverage and strengthening the monitoring of measles and rubella.
As a practical application of multidisciplinary integration， the rapid detection technology of glioma has become increasingly influential in the fields of society， science and technology and economy. This review covers multiple dimensions of rapid glioma detection， including technical application scenarios and future trends. First， this article traces the historical context of the field of rapid glioma detection， emphasizing the remarkable achievements and progress made in the past decade. Secondly， it describes the current popular rapid detection technology for glioma and its application in clinical practice. Finally， this article discusses the challenges of rapid glioma detection， and provides an outlook on the latest advances in this technology， as well as predictions for future developments. To sum up， this article aims to provide a perspective to better understand the current status and future trends in the field of rapid glioma detection technology.
Diabetes mellitus （DM） is a metabolic disease characterized by hyperglycemia. Diabetic peripheral neuropathy （DPN） is one of its late complications， severely affecting the patient's quality of life. Currently， the main clinical diagnostic methods for DPN are nerve conduction study （NCS） and physical examination. However， there are limitations in diagnosing early-stage DPN. Multimodal ultrasound imaging can visualize nerves， detect blood flow signals around the nerve and its surrounding tissues， and measure nerve elasticity， which further aids in assessing the severity of DPN. Therefore， multimodal ultrasound imaging， as a non-invasive diagnostic technique， holds significant value in the early diagnosis of DPN. This review aims to explore the application of multimodal ultrasound imaging in the early diagnosis of DPN.
Dilated cardiomyopathy （DCM） in children is a severe cardiac condition characterized by cardiac dilation and impaired contractile function， and it is the most common type of cardiomyopathy in the pediatric population. The etiology of pediatric DCM is complex， among which the genetic factor plays a significant role. With the advancement of genetic sequencing technologies， significant progress has been made in the genetic research of DCM. DCM exhibits substantial genetic heterogeneity， with mutations in various genes being involved in calcium handling， cytoskeletal dynamics， and ion channel function contributing to the disease. This review will focus on the major pathogenic genes associated with pediatric DCM and their mutation characteristics， including genes encoding cardiac structural proteins （such asTTN，LMNA， etc.） as well as the functions and pathogenic mechanisms of other related genes. This discussion aims to provide a reference for clinical and basic research， facilitating the early diagnosis and effective treatment of pediatric DCM.
Ferroptosis is a distinct form of cell death characterized by iron dependence. Preeclampsia （PE） is a severe disorder occurring during pregnancy， posing significant risks to maternal and fetal health. Excessive iron levels have been observed in the blood of PE patients， potentially arising from hemolysis during pregnancy and interactions with free radicals released from the placenta and vasculature. Excess iron can participate in lipid peroxidation reactions， generating toxic oxidative products that contribute to endothelial cell and placental tissue damage. Recent studies have highlighted a close relationship between PE， lipid peroxidation （LPO） and ferroptosis. LPO refers to the reaction between polyunsaturated fatty acids and free radicals， resulting in cell membrane damage and inflammatory responses. Collectively， the interplay among PE， lipid peroxidation， and ferroptosis is complex. Further exploration of these relationships is crucial for understanding the pathophysiology of PE and developing novel therapeutic strategies， potentially offering new targets and approaches for the prevention and treatment of preeclampsia.
