Mfn2在肿瘤中的研究进展

国际肿瘤学杂志››2021,Vol. 48››Issue (1): 45-47.doi:10.3760/cma.j.cn371439-20200212-00008

魏梦雨, 马力()

河北医科大学第四医院乳腺中心,石家庄 050011

收稿日期:2020-02-12修回日期:2020-08-12出版日期:2021-01-08发布日期:2021-01-21
通讯作者:马力 E-mail:mali1021@126.com
基金资助:
河北省自然科学基金(H2015206230)

Research advances of Mfn2 in tumor

Wei Mengyu, Ma Li()

Department of Breast Disease Center, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

Received:2020-02-12Revised:2020-08-12Online:2021-01-08Published:2021-01-21
Contact:Ma Li E-mail:mali1021@126.com
Supported by:
National Science Foundation of Hebei Province of China(H2015206230)

摘要/Abstract

摘要：

线粒体融合蛋白2(Mfn2)在线粒体融合过程中发挥着重要作用,参与调节线粒体功能和形态学的改变。近年来研究发现,Mfn2在多种恶性肿瘤及其细胞株中具有抑癌作用,包括宫颈癌、肝细胞癌、胰腺癌、乳腺癌和膀胱癌等。Mfn2在恶性肿瘤组织中表达情况的差异,提示其可能在恶性肿瘤细胞增殖、凋亡、侵袭和转移过程中发挥重要作用。Mfn2作为一种肿瘤相关基因,为恶性肿瘤的基因治疗提供了新的思路。

关键词:肿瘤,Mfn2,细胞增殖,细胞凋亡,细胞侵袭

Abstract:

Mitofusin 2 (Mfn2) plays an important role in the process of mitochondrial fusion, and is involved in regulating mitochondrial function and morphological changes. Studies have found that Mfn2 has a tumor suppressor effect in a variety of malignant tumors and their cell lines, including cervical cancer, hepatocellular cancer, pancreatic cancer, breast cancer, and bladder cancer. The difference in the expression of Mfn2 in malignant tumor tissues suggests that Mfn2 may play an important role in the proliferation, apoptosis, invasion and migration of malignant tumor cells. As a cancer-related gene, Mfn2 provides new ideas for gene therapy of malignant tumors.

Key words:Neoplasms,Mfn2,Cell proliferation,Cell apoptosis,Cell invasion

魏梦雨, 马力. Mfn2在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2021, 48(1): 45-47.

Wei Mengyu, Ma Li. Research advances of Mfn2 in tumor[J]. Journal of International Oncology, 2021, 48(1): 45-47.

参考文献25

[1]	Pang G, Xie Q, Yao J. Mitofusin 2 inhibits bladder cancer cell proli-feration and invasion via the Wnt/β-catenin pathway[J]. Oncol Lett, 2019,18(3):2434-2442. DOI: 10.3892/ol.2019.10570. pmid:31402945
[2]	黄健, 卢博, 邹前, 等. Mfn2调节线粒体自噬[J]. 吉林医药学院学报, 2018,39(1):59-61.
[3]	Xu K, Chen G, Li X, et al. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling[J]. Sci Rep, 2017,7:41718. DOI: 10.1038/srep41718. doi:10.1038/srep41718pmid:28176801
[4]	Samanas NB, Engelhart EA, Hoppins S. Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax[J]. Life Sci Alliance, 2020,3(5):e201900527. DOI: 10.26508/lsa.201900527. pmid:32245838
[5]	Han J, Liu J, Zhou Q, et al. Single nucleotide polymorphisms (SNPs) genotyping reveals that Mfn2 polymorphisms are associated with thoracic aortic dissection in Han Chinese population[J]. Med Sci Monit, 2019,25:2419-2428. DOI: 10.12659/MSM.915272. doi:10.12659/MSM.915272pmid:30940795
[6]	Yang Y, Xue LJ, Xue X, et al. MFN2 ameliorates cell apoptosis in a cellular model of Parkinson's disease induced by rotenone[J]. Exp Ther Med, 2018,16(4):3680-3685. DOI: 10.3892/ETM.2018.6595. pmid:30233726
[7]	Chandhok G, Lazarou M, Neumann B. Structure, function, and re-gulation of mitofusin-2 in health and disease[J]. Biol Rev Camb Philos Soc, 2018,93(2):933-949. DOI: 10.1111/brv.12378. doi:10.1111/brv.12378pmid:29068134
[8]	Ma L, Liu Y, Geng C, et al. Estrogen receptor β inhibits estradiol-induced proliferation and migration of MCF-7 cells through regulation of mitofusin 2[J]. Int J Oncol, 2013,42(6):1993-2000. DOI: 10.3892/ijo.2013.1903. doi:10.3892/ijo.2013.1903pmid:23588792
[9]	Van Nieuwenhuysen E, Busschaert P, Laenen A, et al. Loss of 1p36.33 frequent in low-grade serous ovarian cancer[J]. Neoplasia, 2019,21(6):582-590. DOI: 10.1016/j.neo.2019.03.014.
[10]	Huang XB, Song KJ, Chen GB, et al. Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration ad invasion by regulating MAPK pathway[J]. Cancer Bio Ther, 2020,13:1-11. DOI: 10.1080/15384047.2020.1824513.
[11]	Liu X, Sun J, Yuan P, et al. Mfn2 inhibits proliferation and cell-cycle in HeLa cells via Ras-NF-κB signal pathway[J]. Cancer Cell Int, 2019,19:197. DOI: 10.1186/s12935-019-0916-9. doi:10.1186/s12935-019-0916-9pmid:31384172
[12]	Wang W, Liu X, Guo X, et al. Mitofusin-2 triggers cervical carcinoma cell HeLa apoptosis via mitochondrial pathway in mouse model[J]. Cell Physiol Biochem, 2018,46(1):69-81. DOI: 10.1159/000488410. doi:10.1159/000488410pmid:29587277
[13]	Pang CL, Thierry F. Human papillomavirus proteins as prospective therapeutic targets[J]. Microb Pathog, 2013,58:55-65. DOI: 10.1016/j.micpath.2012.11.002. pmid:23164805
[14]	牛亚倩, 常钰玲, 刘芳, 等. 肝细胞癌中微小RNA对mTOR信号通路的调控作用[J]. 国际肿瘤学杂志, 2019,46(10):624-626. DOI: 10.3760/cma.j.issn.1673-422X.2019.10.012.
[15]	Feng X, Zhu K, Liu J, et al. The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy[J]. Onco Targets Ther, 2016,9:3213-3221. DOI: 10.2147/OTT.S98322. pmid:27313467
[16]	Wang W, Xie Q, Zhou X, et al. Mitofusin-2 triggers mitochondria Ca²⁺influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells[J]. Cancer Lett, 2015,358(1):47-58. DOI: 10.1016/j.canlet.2014.12.025. pmid:25541060
[17]	Xu Z, Pothula SP, Wilson JS, et al. Pancreatic cancer and its stroma: a conspiracy theory[J]. World J Gastroenterol, 2014,20(32):11216-11229. DOI: 10.3748/wjg.v20.i32.11216. doi:10.3748/wjg.v20.i32.11216pmid:25170206
[18]	Lin QJ, Yang F, Jin C, et al. Current status and progress of pancreatic cancer in China[J]. World J Gastroenterol, 2015,21(26):7988-8003. DOI: 10.3748/wjg.v21.i26.7988. doi:10.3748/wjg.v21.i26.7988pmid:26185370
[19]	Pan L, Zhou L, Yin W, et al. miR-125a induces apoptosis, meta-bolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission[J]. Int J Oncol, 2018,53(1):124-136. DOI: 10.3892/ijo.2018.4380. pmid:29749475
[20]	Xue R, Meng Q, Lu D, et al. Mitofusin2 induces cell autophagy of pancreatic cancer through inhibiting the PI3K/Akt/mTOR signaling pathway[J]. Oxid Med Cell Longev, 2018,2018:2798070. DOI: 10.1155/2018/2798070. doi:10.1155/2018/2798070pmid:30046371
[21]	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017,67(1):7-30. DOI: 10.3322/caac.21387. pmid:28055103
[22]	Ma LI, Chang Y, Yu L, et al. Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells[J]. Oncol Lett, 2015,10(6):3816-3822. DOI: 10.3892/ol.2015.3748. doi:10.3892/ol.2015.3748
[23]	Zhang J, Sun L, Li W, et al. Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy[J]. Biomed Pharmacother, 2019,114:108844. DOI: 10.1016/j.biopha.2019.108844. pmid:30981108
[24]	Cheng X, Zhou D, Wei J, et al. Cell-cycle arrest at G₂/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines[J]. Neoplasma, 2013,60(6):620-626. DOI: 10.4149/neo_2013_080. pmid:23906296
[25]	Fang CL, Sun DP, Chen HK, et al. Overexpression of mitochondrial GTPase MFN2 represents a negative prognostic marker in human gastric cancer and its inhibition exerts anti-cancer effects[J]. J Cancer, 2017,8(7):1153-1161. DOI: 10.7150/jca.17986. doi:10.7150/jca.17986pmid:28607589