LHPP在恶性肿瘤中的作用

国际肿瘤学杂志››2021,Vol. 48››Issue (7): 420-423.doi:10.3760/cma.j.cn371439-20200630-00080

李田田, 陈敏, 刘怡晨, 彭婕, 施小凤()

江苏大学附属医院血液科,镇江 212000

收稿日期:2020-06-30修回日期:2020-09-17出版日期:2021-07-08发布日期:2021-07-26
通讯作者:施小凤 E-mail:shixiaofeng1977@163.com
基金资助:
国家自然科学基金(81700130);镇江市科技创新资金(SH2017006)

Role of LHPP in malignant tumor

Li Tiantian, Chen Min, Liu Yichen, Peng Jie, Shi Xiaofeng()

Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China

Received:2020-06-30Revised:2020-09-17Online:2021-07-08Published:2021-07-26
Contact:Shi Xiaofeng E-mail:shixiaofeng1977@163.com
Supported by:
National Natural Science Foundation of China(81700130);Science and Technology Innovation Fund Project of Zhenjiang of China(SH2017006)

摘要/Abstract

摘要：

磷酸赖氨酸磷酸组氨酸无机焦磷酸盐磷酸酶(LHPP)是一种从蠕虫到人类进化中高度保守的组氨酸磷酸酶。最近研究表明,LHPP作为一种肿瘤抑制因子,可通过参与多种细胞信号通路和蛋白质磷酸化的调节,抑制肿瘤细胞增殖、生长和迁移,促进凋亡。因此,对LHPP作用机制的深入研究,有助于寻找诊断和预测相关肿瘤的最佳分子标志物及治疗靶点,对于改善相关肿瘤的预后至关重要。

关键词:肿瘤,磷酸肌醇3-激酶,预后,LHPP

Abstract:

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a highly conserved histidine phosphatase from worms to humans in evolution. Recent studies have shown that LHPP, as a tumor suppressor, can inhibit the proliferation, growth and migration of the cells and promote apoptosis by participating in the regulation of various cell signaling pathways and protein phosphorylation. Therefore, the deeply study on the mechanism of LHPP is helpful to explore the best diagnostic markers and therapeutic targets for related tumors, which is essential for improving the prognosis of related tumors.

Key words:Neoplasms,Phosphatidylinositol 3-kinase,Prognosis,LHPP

李田田, 陈敏, 刘怡晨, 彭婕, 施小凤. LHPP在恶性肿瘤中的作用[J]. 国际肿瘤学杂志, 2021, 48(7): 420-423.

Li Tiantian, Chen Min, Liu Yichen, Peng Jie, Shi Xiaofeng. Role of LHPP in malignant tumor[J]. Journal of International Oncology, 2021, 48(7): 420-423.

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