国际肿瘤学杂志››2021,Vol. 48››Issue (4): 212-215.doi:10.3760/cma.j.cn371439-20200722-00042

• 综述 •上一篇下一篇

IL-35、IL-39、IL-27在肿瘤微环境中的调节作用

刘赛赛, 袁东亚()

  1. 西藏民族大学西藏自治区高原相关疾病分子遗传机制与干预研究重点实验室,咸阳 712082
  • 收稿日期:2020-07-22修回日期:2020-12-20出版日期:2021-04-08发布日期:2021-06-18
  • 通讯作者:袁东亚 E-mail:dy62@163.com

Regulation of IL-35, IL-39 and IL-27 in tumor microenvironment

Liu Saisai, Yuan Dongya()

  1. Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xizang Minzu University, Xianyang 712082, China
  • Received:2020-07-22Revised:2020-12-20Online:2021-04-08Published:2021-06-18
  • Contact:Yuan Dongya E-mail:dy62@163.com

摘要:

白细胞介素(IL)家族能直接或间接地刺激肿瘤细胞增殖、存活和扩散,并进一步塑造肿瘤微环境,从而在一定程度上影响肿瘤的生长与转化。研究发现IL-12家族的新成员IL-35、IL-39、IL-27在多种肿瘤中发挥相关的特异性免疫功能,可能是肿瘤研究的重要靶向分子。

关键词:肿瘤微环境,免疫,细胞因子

Abstract:

The interleukin family can directly or indirectly stimulates the proliferation, survival and diffusion of tumor cells, and further shapes the tumor microenvironment, thus affecting the tumor growth and transformation to a certain extent. Studies show that the new numbers of IL-12 family, IL-35, IL-39 and IL-27, play the relevant specific immune functions in a variety of tumors, which may be important target molecules for tumors research.

Key words:Tumor microenvironment,Immunity,Cytokines