长非编码RNA作为竞争性内源RNA在黑色素瘤中的研究进展

摘要/Abstract

摘要：

近年来,长非编码RNA(lncRNA)作为竞争性内源RNA(ceRNA)在黑色素瘤中的研究日益增多。lncRNA在黑色素瘤中呈现高表达或低表达,并通过ceRNA机制竞争性地与miRNA结合,影响miRNA下游靶基因mRNA的表达,从而发挥癌基因或抑癌基因的作用。了解lncRNA作为ceRNA在黑色素瘤中的作用,可为未来黑色素瘤的诊断及治疗靶点研究提供新思路。

洪安澜, 曹蒙, 王焱, 方方. 长非编码RNA作为竞争性内源RNA在黑色素瘤中的研究进展[J]. 国际肿瘤学杂志, 2022, 49(1): 61-64.

Hong Anlan, Cao Meng, Wang Yan, Fang Fang. Research progress on lncRNAs as members of ceRNA network in melanoma[J]. Journal of International Oncology, 2022, 49(1): 61-64.

参考文献37

[1]	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1):7-30. DOI: 10.3322/caac.21590. doi:10.3322/caac.21590
[2]	Riefolo M, Porcellini E, Dika E, et al. Interplay between small and long non-coding RNAs in cutaneous melanoma: a complex jigsaw puzzle with missing pieces[J]. Mol Oncol, 2019, 13(1):74-98. DOI: 10.1002/1878-0261.12412. doi:10.1002/1878-0261.12412pmid:30499222
[3]	Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways[J]. Cancer Cell, 2016, 29(4):452-463. DOI: 10.1016/j.ccell.2016.03.010. doi:S1535-6108(16)30092-7pmid:27070700
[4]	Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypojournal: the rosetta stone of a hidden RNA language?[J]. Cell, 2011, 146(3):353-358. DOI: 10.1016/j.cell.2011.07.014. doi:10.1016/j.cell.2011.07.014
[5]	Yu X, Zheng H, Tse G, et al. Long non-coding RNAs in melanoma[J]. Cell Prolif, 2018, 51(4):e12457. DOI: 10.1111/cpr.12457. doi:10.1111/cpr.12457
[6]	Luan W, Li R, Liu L, et al. Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p[J]. Oncotarget, 2017, 8(49):85401-85414. DOI: 10.18632/oncotarget.19910. doi:10.18632/oncotarget.19910
[7]	Cantile M, Scognamiglio G, Marra L, et al. HOTAIR role in melanoma progression and its identification in the blood of patients with advanced disease[J]. J Cell Physiol, 2017, 232(12):3422-3432. DOI: 10.1002/jcp.25789. doi:10.1002/jcp.25789pmid:28067428
[8]	Wang P, Hu L, Fu G, et al. LncRNA MALAT1 promotes the proli-feration, migration, and invasion of melanoma cells by downregulating miR-23a[J]. Cancer Manag Res, 2020, 12:6553-6562. DOI: 10.2147/CMAR.S249348. doi:10.2147/CMAR.S249348pmid:32801893
[9]	Li F, Li X, Qiao L, et al. MALAT1 regulates miR-34a expression in melanoma cells[J]. Cell Death Dis, 2019, 10(6):389. DOI: 10.1038/s41419-019-1620-3. doi:10.1038/s41419-019-1620-3
[10]	Sun Y, Cheng H, Wang G, et al. Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation[J]. Oncotarget, 2017, 8(2):3509-3518. DOI: 10.18632/oncotarget.13862. doi:10.18632/oncotarget.13862
[11]	Han C, Tang F, Chen J, et al. Knockdown of lncRNA-UCA1 inhi-bits the proliferation and migration of melanoma cells through modulating the miR-28-5p/HOXB3 axis[J]. Exp Ther Med, 2019, 17(5):4294-4302. DOI: 10.3892/etm.2019.7421. doi:10.3892/etm.2019.7421
[12]	Chen X, Gao J, Yu Y, et al. Long non-coding RNA UCA1 targets miR-185-5p and regulates cell mobility by affecting epithelial-mesenchymal transition in melanoma via Wnt/β-catenin signaling pathway[J]. Gene, 2018, 676:298-305. DOI: 10.1016/j.gene.2018.08.065. doi:10.1016/j.gene.2018.08.065
[13]	Wei Y, Sun Q, Zhao L, et al. LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G₀/G₁cell cycle arrest in melanoma[J]. Med Oncol, 2016, 33(8):88. DOI: 10.1007/s12032-016-0804-2. doi:10.1007/s12032-016-0804-2
[14]	Chen X, Gao G, Liu S, et al. Long noncoding RNA PVT1 as a novel diagnostic biomarker and therapeutic target for melanoma[J]. Biomed Res Int, 2017, 2017:7038579. DOI: 10.1155/2017/7038579. doi:10.1155/2017/7038579
[15]	Wang BJ, Ding HW, Ma GA. Long noncoding RNA PVT1 promotes melanoma progression via endogenous sponging miR-26b[J]. Oncol Res, 2018, 26(5):675-681. DOI: 10.3727/096504017X-14920318811730. doi:10.3727/096504017X-14920318811730
[16]	Zhou H, Sun L, Wan F. Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells[J]. Oncol Lett, 2019, 18(5):4393-4402. DOI: 10.3892/ol.2019.10848. doi:10.3892/ol.2019.10848pmid:31611948
[17]	Liu W, Feng Q, Liao W, et al. TUG1 promotes the expression of IFITM3 in hepatocellular carcinoma by competitively binding to miR-29a[J]. J Cancer, 2021, 12:6905-6920. DOI: 10.7150/jca.57477. doi:10.7150/jca.57477
[18]	Yuan JB, Gu L, Chen L, et al. Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis[J]. Mol Ther Oncolytics, 2021, 22:36-51. DOI: 10.1016/j.omto.2021.04.008. doi:10.1016/j.omto.2021.04.008
[19]	Liu Q, Zhang W, Luo L, et al. Long noncoding RNA TUG1 regulates the progression of colorectal cancer through miR-542-3p/TRIB2 axis and Wnt/β-catenin pathway[J]. Diagn Pathol, 2021, 16(1):47. DOI: 10.1186/s13000-021-01101-7. doi:10.1186/s13000-021-01101-7
[20]	Wang Y, Liu G, Ren L, et al. Long non-coding RNA TUG1 recruits miR-29c-3p from its target gene RGS1 to promote proliferation and metastasis of melanoma cells[J]. Int J Oncol, 2019, 54(4):1317-1326. DOI: 10.3892/ijo.2019.4699. doi:10.3892/ijo.2019.4699
[21]	Long J, Menggen Q, Wuren Q, et al. Long noncoding RNA taurine-upregulated gene1 (TUG1) promotes tumor growth and metastasis through TUG1/miR-129-5p/astrocyte-elevated gene-1 (AEG-1) axis in malignant melanoma[J]. Med Sci Monit, 2018, 24:1547-1559. DOI: 10.12659/msm.906616. doi:10.12659/msm.906616
[22]	Fan J, Kang X, Zhao L, et al. Long noncoding RNA CCAT1 functions as a competing endogenous RNA to upregulate ITGA9 by sponging miR-296-3p in melanoma[J]. Cancer Manag Res, 2020, 12:4699-4714. DOI: 10.2147/CMAR.S252635. doi:10.2147/CMAR.S252635
[23]	Lv L, Jia JQ, Chen J. The lncRNA CCAT1 upregulates proliferation and invasion in melanoma cells via suppressing miR-33a[J]. Oncol Res, 2018, 26(2):201-208. DOI: 10.3727/096504017X1-4920318811749. doi:10.3727/096504017X1-4920318811749
[24]	Pan B, Lin X, Zhang L, et al. Long noncoding RNA X-inactive specific transcript promotes malignant melanoma progression and oxaliplatin resistance[J]. Melanoma Res, 2019, 29(3):254-262. DOI: 10.1097/CMR.0000000000000560. doi:10.1097/CMR.0000000000000560
[25]	Tian K, Sun D, Chen M, et al. Long noncoding RNA X-inactive specific transcript facilitates cellular functions in melanoma via miR-139-5p/ROCK1 pathway[J]. Onco Targets Ther, 2020, 13:1277-1287. DOI: 10.2147/OTT.S225661. doi:10.2147/OTT.S225661
[26]	Ma MH, An JX, Zhang C, et al. ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression[J]. Cancer Cell Int, 2019, 19:27. DOI: 10.1186/s12935-019-0742-0. doi:10.1186/s12935-019-0742-0
[27]	Xia W, Jie W. ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway[J]. Cancer Cell Int, 2020, 20:94. DOI: 10.1186/s12935-020-1098-1. doi:10.1186/s12935-020-1098-1pmid:32231464
[28]	Wang Q, Zhang R, Liu D. Long non-coding RNA ZEB1-AS1 indicates poor prognosis and promotes melanoma progression through targeting miR-1224-5p[J]. Exp Ther Med, 2019, 17(1):857-862. DOI: 10.3892/etm.2018.7005. doi:10.3892/etm.2018.7005
[29]	Siena ÁDD, Plaça JR, Araújo LF, et al. Whole transcriptome analysis reveals correlation of long noncoding RNA ZEB1-AS1 with invasive profile in melanoma[J]. Sci Rep, 2019, 9(1):11350. DOI: 10.1038/s41598-019-47363-6. doi:10.1038/s41598-019-47363-6
[30]	Moradi MT, Fallahi H, Rahimi Z. Interaction of long noncoding RNA MEG3 with miRNAs: a reciprocal regulation[J]. J Cell Biochem, 2019, 120(3):3339-3352. DOI: 10.1002/jcb.27604. doi:10.1002/jcb.27604
[31]	Al-Rugeebah A, Alanazi M, Parine NP. MEG3: an oncogenic long non-coding RNA in different cancers[J]. Pathol Oncol Res, 2019, 25(3):859-874. DOI: 10.1007/s12253-019-00614-3. doi:10.1007/s12253-019-00614-3pmid:30793226
[32]	Long J, Pi X. lncRNA-MEG3 suppresses the proliferation and invasion of melanoma by regulating CYLD expression mediated by sponging miR-499-5p[J]. Biomed Res Int, 2018, 2018:2086564. DOI: 10.1155/2018/2086564. doi:10.1155/2018/2086564
[33]	Wu L, Zhu L, Li Y, et al. LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis[J]. Cancer Cell Int, 2020, 20:12. DOI: 10.1186/s12935-019-1087-4. doi:10.1186/s12935-019-1087-4
[34]	Kolenda T, Rutkowski P, Michalak M, et al. Plasma lncRNA expression profile as a prognostic tool in BRAF-mutant metastatic melanoma patients treated with BRAF inhibitor[J]. Oncotarget, 2019, 10(39):3879-3893. DOI: 10.18632/oncotarget.26989. doi:10.18632/oncotarget.26989pmid:31231466
[35]	Yu X, Zheng H, Tse G, et al. CASC2: an emerging tumour-suppressing long noncoding RNA in human cancers and melanoma[J]. Cell Prolif, 2018, 51(6):e12506. DOI: 10.1111/cpr.12506. doi:10.1111/cpr.12506
[36]	Wang Z, Wang X, Zhou H, et al. Long non-coding RNA CASC2 inhibits tumorigenesis via the miR-181a/PLXNC1 axis in melanoma[J]. Acta Biochim Biophys Sin (Shanghai), 2018, 50(3):263-272. DOI: 10.1093/abbs/gmx148. doi:10.1093/abbs/gmx148
[37]	Zhang Y, Qian W, Feng F, et al. Upregulated lncRNA CASC2 may inhibit malignant melanoma development through regulating miR-18a-5p/RUNX1[J]. Oncol Res, 2019, 27(3):371-377. DOI: 10.3727/096504018X15178740729367. doi:10.3727/096504018X15178740729367

长非编码RNA作为竞争性内源RNA在黑色素瘤中的研究进展

Research progress on lncRNAs as members of ceRNA network in melanoma

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