国际肿瘤学杂志

国际肿瘤学杂志››2022,Vol. 49››Issue (5): 282-284.doi:10.3760/cma.j.cn371439-20211210-00052

• 论著 •上一篇下一篇

HSP90α、HSP90β在结直肠癌组织中的表达及临床意义

陈存宝, 鲁守堂, 王若谷, 杨建树, 李建祺, 甄亚男(), 徐忠法()

  1. betway必威登陆网址 （betway.com ）胃肠病研究所（临床中心）;betway必威登陆网址 第三附属医院（betway.com 附属医院）胃肠外科,济南 250031
  • 收稿日期:2021-12-10修回日期:2022-03-20出版日期:2022-05-08发布日期:2022-05-31
  • 通讯作者:甄亚男,徐忠法,孙娜 E-mail:drzhenyanan@126.com;xzfa2216@126.com

Expressions of HSP90α and HSP90β in colorectal cancer tissues and their clinical significances

Chen Cunbao, Lu Shoutang, Wang Ruogu, Yang Jianshu, Li Jianqi, Zhen Yanan(), Xu Zhongfa()

  1. Gastroenterology Research Institute and Clinical Center, Shandong First Medical University （Shandong Academy of Medical Sciences）; Department of Gastrointestinal Surgery, Third Affiliated Hospital of Shandong First Medical University （Affiliated Hospital of Shandong Academy of Medical Sciences）, Jinan 250031, China
  • Received:2021-12-10Revised:2022-03-20Online:2022-05-08Published:2022-05-31
  • Contact:Zhen Yanan,Xu Zhongfa E-mail:drzhenyanan@126.com;xzfa2216@126.com

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摘要：

目的研究热休克蛋白（HSP）90α、HSP90β在结直肠癌组织和癌旁组织中的表达,探讨HSP90α、HSP90β与结直肠癌患者临床病理特征的关系,并分析两者的相关性。方法选取2016年1月至2020年12月betway必威登陆网址 第三附属医院胃肠外科收治的117例结直肠癌患者的肿瘤组织及癌旁组织,采用免疫组织化学法检测HSP90α和HSP90β的表达水平,分析二者与患者临床病理特征的关系以及二者表达的相关性。结果HSP90α在结直肠癌组织和癌旁组织中的阳性表达率分别为74.4%（87/117）、12.0%（14/117）,两组差异具有统计学意义（χ2=92.83,P<0.001）;HSP90β在结直肠癌组织和癌旁组织中的阳性表达率分别为61.5%（72/117）、10.3%（12/117）,两组差异具有统计学意义（χ2=66.86,P<0.001）。HSP90α的表达与肿瘤位置（χ2=8.67,P=0.003）、血管侵犯（χ2=8.68,P=0.003）、淋巴结转移（χ2=8.52,P=0.004）、T分期（χ2=21.07,P<0.001）、N分期（χ2=11.94,P=0.003）、M分期（χ2=5.37,P=0.020）、病理分期（χ2=25.64,P<0.001）具有相关性;HSP90β的表达与淋巴结转移（χ2=4.03,P=0.045）、T分期（χ2=11.09,P=0.007）、N分期（χ2=6.56,P=0.038）、M分期（χ2=12.43,P<0.001）、病理分期（χ2=17.34,P=0.001）具有相关性。两种蛋白在结直肠癌组织中的表达呈正相关（r=0.42,P<0.001）。结论HSP90α、HSP90β在结直肠癌组织中的表达明显高于癌旁组织,并均与淋巴结转移和病理分期有关;二者表达呈正相关,可能共同参与了结直肠癌的发生发展,有望成为新的肿瘤标志物。

关键词:结直肠肿瘤,热休克蛋白90α,热休克蛋白90β

Abstract:

ObjectiveTo study the expressions of heat shock protein （HSP）90α and HSP90β in colorectal cancer and paracancer tissues, and to investigate the relationships between HSP90α, HSP90β and clinicopathological features of colorectal cancer patients, and to analyze their correlation.MethodsThe tumor tissues and paracancer tissues of 117 patients with colorectal cancer were selected from the Department of Gastrointestinal Surgery, Third Affiliated Hospital of Shandong First Medical University from January 2016 to December 2020. The expression levels of HSP90α and HSP90β were detected by immunohistochemistry, and the relationships between the two proteins and clinicopathological features and the correlation of their expressions were analyzed.ResultsThe positive expression rates of HSP90α in colorectal cancer tissues and paracancer tissues were 74.4% （87/117） and 12.0% （14/117）, and there was a statistically significant difference （χ2=92.83,P<0.001）. The positive expression rate of HSP90β in colorectal cancer tissues and paracancer tissues was 61.5% （72/117） and 10.3% （12/117）, and there was a statistically significant difference （χ2=66.86,P<0.001）. The expression of HSP90α was correlated with tumor location （χ2=8.67,P=0.003）, vascular invasion （χ2=8.68,P=0.003）, lymph node metastasis （χ2=8.52,P=0.004）, T stage （χ2=21.07,P<0.001）, N stage （χ2=11.94,P=0.003）, M stage （χ2=5.37,P=0.020）, pathological stage （χ2=25.64,P<0.001）. The expression of HSP90β was correlated with lymph node metastasis （χ2=4.03,P=0.045）, T stage （χ2=11.09,P=0.007）, N stage （χ2=6.56,P=0.038）, M stage （χ2=12.43,P<0.001）, pathological stage （χ2=17.34,P=0.001）. There was a positive correlation between the expressions of the two proteins in colorectal cancer tissues （r=0.42,P<0.001）.ConclusionThe expressions of HSP90α and HSP90β in colorectal cancer tissues are significantly higher than those in paracancer tissues, and they are related to lymph node metastasis and pathological stage. There is a positive correlation between the two proteins, which may be involved in the occurrence and development of colorectal cancer and are expected to become new tumor markers.

Key words:Colorectal neoplasms,HSP90α,HSP90β