国际肿瘤学杂志››2014,Vol. 41››Issue (1): 52-55.doi:10.3760/cma.j.issn.1673-422X.2014.01.017

• 综述 •上一篇下一篇

恶性胸膜间皮瘤靶向治疗进展

程蕾, 许亚萍, 毛伟敏

  1. 310022杭州,浙江省肿瘤医院放疗科
  • 出版日期:2014-01-08发布日期:2014-01-22
  • 通讯作者:毛伟敏,E-mail:weiminmao1218@163.com E-mail:weiminmao1218@163.com

Molecular targeted therapy of malignant pleural mesothelioma

Cheng Lei, Xu Yaping, Mao Weimin

  1. Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2014-01-08Published:2014-01-22
  • Contact:Mao Weimin E-mail:weiminmao1218@163.com

摘要:恶性胸膜间皮瘤(MPM)是胸膜罕见的恶性肿瘤,由于其潜伏期约为20年,目前正是该疾病的高发阶段。由于该疾病发现时大部分已处于晚期,除了经典的培美曲塞联合顺铂一线化疗方案疗效确定之外,手术、放疗及二三线化疗疗效仍未知。近年来发展迅猛的分子靶向治疗又为MPM的个体化治疗提供了新的方向。

关键词:基因,肿瘤,恶性胸膜间皮瘤,分子靶向治疗

Abstract:Malignant pleural mesothelioma (MPM) is a rare form of cancer with latency period of 20 years, and it is now a period of high flows of MPM. It is often detected in late stages, and the efficacy of surgery, radiotherapy and second/thirdline chemotherapy still remains unknown except the classical firstline chemotherapy regimen contains pemetrexed and cisplatin. With the development of molecular targeted therapy, a new direction for individual therapy of MPM patient has been provided for the past few years.

Key words:Genes,Neoplasms,Malignant pleural mesothelioma,Molecular targeted therapy