内质网应激在肿瘤发展中的作用

国际肿瘤学杂志››2014,Vol. 41››Issue (2): 84-87.doi:10.3760/cma.j.issn.1673-422X.2014.02.002

内质网应激在肿瘤发展中的作用

马瑞金, 杨宇

150086哈尔滨医科大学附属第二医院肿瘤内科

收稿日期:2013-09-24修回日期:2014-01-02出版日期:2014-02-08发布日期:2014-01-26
通讯作者:杨宇，E-mail: yangy@medmail.com.cn E-mail:yangy@medmail.com.cn
基金资助:

黑龙江省自然科学基金（D200862）

Role of endoplasmic reticulum stress in tumor progression

Ma Ruijin, Yang Yu

Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2013-09-24Revised:2014-01-02Online:2014-02-08Published:2014-01-26
Contact:Yang Yu E-mail:yangy@medmail.com.cn

摘要/Abstract

摘要：内质网应激(ERS)作为一种细胞应激过程，在多种细胞、多种情况下可被激活。近年来发现，ERS存在于多种肿瘤细胞中。体内外研究证实ERS参与介导肿瘤细胞的凋亡、自噬性死亡和免疫原性细胞死亡，以及促进肿瘤细胞存活、调控细胞周期等多个过程，从而在肿瘤细胞中发挥多种作用。因此研究ERS将有助于进一步了解肿瘤的发展及转归。

马瑞金, 杨宇. 内质网应激在肿瘤发展中的作用[J]. 国际肿瘤学杂志, 2014, 41(2): 84-87.

Ma Ruijin, Yang Yu. Role of endoplasmic reticulum stress in tumor progression[J]. Journal of International Oncology, 2014, 41(2): 84-87.

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