信号通路调控上皮间质转化参与肿瘤侵袭

摘要/Abstract

摘要：上皮间质转化（EMT）是上皮细胞向间充质细胞分化的过程，EMT在恶性肿瘤的侵袭转移中广泛存在。EMT的发生与多种细胞因子、信号转导通路及转录因子有关，受多种影响因素的共同调控。上皮细胞表型的不同程度转化是细胞内外信号传递共同作用的结果。细胞外信号通过与细胞表面特异性受体相结合将信号转入细胞内，再通过胞内的信号转导途径，活化不同的核内转导因子，最终调节转导基因的表达。

关键词:肿瘤侵润,肿瘤转移,上皮-间质转化

Abstract:Epithelialmesenchymal transition (EMT) is a differentiation process of epithelial cells into mesenchymals, which is widespread in the invasion and metastasis of malignant tumor. Studies show that EMT is influenced by a variety of factors such as cytokines, signaling pathways and transcription factors. Studies also show that intracellular and extracellular signal transmission could induce EMT. Signal transduction is a process which involves ligandreceptor binding in the extracellular, going into the cell and activating different nuclear transduction factor through intracellular signal transduction pathway.

Key words:Neoplasm invasiveness,Neoplasm metastasis,Epithelialmesenchymal transition

朱蕾, 隋华, 邓皖利. 信号通路调控上皮间质转化参与肿瘤侵袭[J]. 国际肿瘤学杂志, 2014, 41(3): 172-177.

ZHU Lei, SUI Hua, DENG Wan-Li. Advances in signal transduction pathway regulating EMT in tumor invasion and metastasis[J]. Journal of International Oncology, 2014, 41(3): 172-177.

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