食管癌淋巴结转移研究进展

摘要/Abstract

摘要：淋巴结是食管癌转移的最主要部位，淋巴结的转移状况是判断食管癌患者预后的重要因素。食管癌早期即可出现淋巴结的转移，其转移具有就近转移和特定区域高发的较固定规律，也具有广泛转移和跳跃性转移的特点。因此研究食管癌淋巴结的转移规律能够帮助确定食管癌患者手术淋巴结清扫的范围和食管癌的放疗照射靶区。

关键词:食管肿瘤,淋巴转移,淋巴结切除术,淋巴照射

Abstract:Lymph nodes （LN）are the main parts of the esophageal cancer metastasis, and the current status of LN is the important indicator of prognosis. LN metastasis appears in early stage of esophageal cancer. One side, LN metastasis easily appears in the regions near the tumor and some special areas. On the other side, LN metastasis has the characteristics of wide metastasis and skip metastasis. Therefore, the researches of the pattern of esophageal cancer lymph node metastasis can help to comform the scope of the esophageal cancer lymph node dissection and the target regions of radiotherapy.

Key words:Esophageal neoplasms,Lymphatic metastasis,Lymph node excision,Lymphatic irradiation

应吟吟, 许亚萍, 毛伟敏. 食管癌淋巴结转移研究进展[J]. 国际肿瘤学杂志, 2014, 41(12): 921-925.

YING Yin-Yin, XU Ya-Ping, MAO Wei-Min. Research progress of lymph node metastasis in esophageal cancer[J]. Journal of International Oncology, 2014, 41(12): 921-925.

参考文献

［1］王永岗, 汪良骏, 张德超, 等. 胸段食管鳞癌淋巴结转移特点及临床意义［J］. 中华肿瘤杂志, 2000, 22(3): 241243. ［2］ Kim DU, Lee JH, Min BH, et al. Risk factors of lymph node metastasis in T1 esophageal squamous cell carcinoma［J］. J Gastroenterol Hepatol, 2008, 23(4): 619625. ［3］陈跃军, 邹求益, 朱广, 等. 胸段食管癌淋巴结转移特点的临床研究［J］. 中华胃肠外科杂志, 2013, 16(9): 835837. ［4］ Gaur P, Sepesi B, Hofstetter WL, et al. Endoscopic esophageal tumor length: a prognostic factor for patients with esophageal cancer［J］. Cancer, 2011, 117(1): 6369. ［5］ Wu N, Pang LW, Chen ZM, et al. Tumour length is an independent prognostic factor of esophageal squamous cell carcinomas［J］. Chin Med J (Engl), 2012, 125(24): 44454448. ［6］刘超,葛红,买玲, 等. 胸段食管鳞癌淋巴结转移规律及其影响因素分析［J］. 中华肿瘤防治杂志, 2013, 20(13):10251029. ［7］ Kaneshiro DK, Post JC, Rybicki L, et al. Clinical significance of the duplicated muscularis mucosae in Barrett esophagusrelated superficial adenocarcinoma［J］. Am J Surg Pathol, 2011, 35(5): 697700. ［8］ Raja S, Rice TW, Goldblum JR, et al. Esophageal submucosa: the watershed for esophageal cancer［J］. J Thorac Cardiovasc Surg, 2011, 142(6): 14031411. ［9］ Feng JF, Zhao Q, Chen QX. Prognostic value of subcarinal lymph node metastasis in patients with esophageal squamous cell carcinoma［J］. Asian Pac J Cancer Prev, 2013, 14(5): 31833186. ［10］ Kunisaki C, Makino H, Kimura J, et al. Impact of lymphnode metastasis site in patients with thoracic esophageal cancer［J］. J Surg Oncol, 2010, 101(1): 3642. ［11］ Akutsu Y, Shuto K, Kono T, et al. The number of pathologic lymph nodes involved is still a significant prognostic factor even after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma［J］. J Surg Oncol, 2012, 105(8): 756760. ［12］ Kelty CJ, Kennedy CW, Falk GL. Ratio of metastatic lymph nodes to total number of nodes resected is prognostic for survival in esophageal carcinoma［J］. J Thorac Oncol, 2010, 5(9): 14671471. ［13］冯键, 茅腾, 陈文虎, 等. 转移淋巴结的数量和范围对食管癌预后的影响［J］. 中华胃肠外科杂志, 2011, 14(9):715718. ［14］祝淑钗, 宋长亮, 沈文斌. 食管癌根治性切除术后患者预后的影响因素分析［J］. 中华肿瘤杂志, 2012, 34(4): 281286. ［15］孙志钢, 王洲, 刘相燕，等. pN0食管癌IvorLewis手术后淋巴结转移性复发的危险因素［J］. 中华胸心血管外科杂志, 2011, 27(2): 108111. ［16］ Koenig AM, Prenzel KL, Bogoevski D, et al. Strong impact of micrometastatic tumor cell load in patients with esophageal carcinoma［J］. Ann Surg Oncol, 2009, 16(2): 454462. ［17］ Sato F, Shimada Y, Li Z, et al. Lymph node micrometastasis and prognosis in patients with oesophageal squamous cell carcinoma［J］. Br J Surg, 2001, 88(3): 426432. ［18］ Prenzel KL, Hlscher AH, Drebber U, et al. Prognostic impact of nodal micrometastasis in early esophageal cancer［J］. Eur J Surg Oncol, 2012, 38(4): 314318. ［19］ Uenosono Y, Arigami T, Yanagita S, et al. Sentinel node navigation surgery is acceptable for clinical T1 and N0 esophageal cancer［J］. Ann Surg Oncol, 2011, 18(7): 20032009. ［20］ Thompson SK, Bartholomeusz D, Jamieson GG. Sentinel lymph node biopsy in esophageal cancer: should it be standard of care? ［J］. J Gastrointest Surg, 2011, 15(10): 17621768. ［21］ Groth SS, Virnig BA, Whitson BA, et al. Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: data from the Surveillance Epidemiology and End Results database［J］. J Thorac Cardiovasc Surg, 2010, 139(3): 612620. ［22］ Greenstein AJ, Litle VR, Swanson SJ, et al. Effect of the number of lymph nodes sampled on postoperative survival of lymph nodenegativeesophageal cancer［J］. Cancer, 2008, 112(6): 12391246. ［23］ Rizk NP, Ishwaran H, Rice TW, et al. Optimum lymphadenectomy for esophageal cancer［J］. Ann Surg, 2010, 251(1): 4650. ［24］ Shridhar R, Hoffe SE, Almhanna K, et al. Lymph node harvest in esophageal cancer after neoadjuvant chemoradiotherapy［J］. Ann Surg Oncol, 2013, 20(9): 30383043. ［25］ Zhu Z, Yu W, Li H, et al. Nodal skip metastasis is not a predictor of survival in thoracic esophageal squamous cell carcinoma［J］. Ann Surg Oncol, 2013, 20(9): 30523058. ［26］ Igaki H, Tachimori Y, Kato H. Improved survival for patients with upper and/or middle mediastinal lymph node metastasis of squamous cell carcinoma of the lower thoracic esophagus treated with 3field dissection［J］. Ann Surg, 2004, 239(4): 483490. ［27］ Fang WT, Chen WH, Chen Y, et al. Selective threefield lymphadenectomy for thoracic esophageal squamous carcinoma［J］. Dis Esophagus, 2007, 20(3): 206211. ［28］ Ma JB, Song YP, Yu JM, et al. Feasibility of involvedfield conformal radiotherapy for cervical and upperthoracic esophageal cancer［J］. Onkologie, 2011, 34(11): 599604.

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Research progress of lymph node metastasis in esophageal cancer

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