淋巴管生成相关因子在结直肠癌中的表达和作用

国际肿瘤学杂志››2015,Vol. 42››Issue (7): 542-544.doi:10.3760/cma.j.issn.1673-422X.2015.07.018

淋巴管生成相关因子在结直肠癌中的表达和作用

张月蒙，孙姗姗，刘文志，高文仓

116001 大连大学附属中山医院胃肠外科（张月蒙、刘文志）；山东省桓台县人民医院肿瘤科（孙姗姗）；大连大学附属新华医院肿瘤科（高文仓）

出版日期:2015-07-08发布日期:2015-05-26
通讯作者:高文仓 E-mail:gaowencang@sohu.com

Expression and effect of related factors of lymphangiogenesis in colorectal cancer

Zhang Yuemeng, Sun Shanshan, Liu Wenzhi, Gao Wencang

Department of Gastrointestinal Surgery, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China

Online:2015-07-08Published:2015-05-26
Contact:Gao Wencang E-mail:gaowencang@sohu.com

摘要/Abstract

摘要：结直肠癌淋巴转移严重影响其预后及生存，淋巴管生成在淋巴转移中发挥重要作用。近来研究发现COX2、MMP7等因子可以促进VEGFC的表达，而VEGFC与其受体结合后激活相应信号通路可以促进淋巴管生成。目前，随着以上淋巴管生成相关因子在结直肠癌中被发现，结直肠癌淋巴管生成过程愈发清楚，但此类因子的确切作用机制尚待进一步研究。

关键词:结直肠肿瘤,内皮生长因子,淋巴管生成

Abstract:The lymphatic metastasis affects prognosis and survival of colorectal cancer seriously, and lymphangiogenesis plays an important role in the lymphatic metastasis. Many factors such as COX2 and MMP7 which are found in many researches recently can promote the expression of VEGFC which can promote the lymphangiogenesis by connecting with its receptor and activating the relevant signal pathway. At present, as these related factors of lymphangiogenesis are found in colorectal cancer, the process of lymphangiogenesis in colorectal cancer becomes more clear, but the exact mechanism of these factors needs to be researched in future.

Key words:Colorectal neoplasms,Endothelial growth factors,Lymphangiogenesis

张月蒙，孙姗姗，刘文志，高文仓. 淋巴管生成相关因子在结直肠癌中的表达和作用[J]. 国际肿瘤学杂志, 2015, 42(7): 542-544.

Zhang Yuemeng, Sun Shanshan, Liu Wenzhi, Gao Wencang. Expression and effect of related factors of lymphangiogenesis in colorectal cancer[J]. Journal of International Oncology, 2015, 42(7): 542-544.

参考文献

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