环指蛋白43基因与肿瘤

国际肿瘤学杂志››2016,Vol. 43››Issue (1): 23-25.doi:10.3760/cma.j.issn.1673-422X.2016.01.006

王世雄, 李耀平

030013 太原，山西医科大学附属肿瘤医院结直肠肛门外科

收稿日期:2015-08-03出版日期:2016-01-08发布日期:2015-12-03
通讯作者:李耀平 E-mail:liyaoping1600@sina.com

Ring finger protein 43 gene and cancer

Wang Shixiong, Li Yaoping

Department of Colorectal & Anal Surgery, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030013, China

Received:2015-08-03Online:2016-01-08Published:2015-12-03
Contact:Li Yaoping E-mail:liyaoping1600@sina.com

摘要/Abstract

摘要：环指蛋白43（RNF43）基因与人类多种肿瘤的发生发展密切相关，与其相关的肿瘤发病机制主要是RNF43基因的异常表达和基因突变。其编码的蛋白在结直肠癌、肝癌中通过多种信号通路参与肿瘤细胞的增殖、凋亡、侵袭，影响肿瘤的发生发展，发挥癌基因的作用；而在卵巢黏液性肿瘤、胰腺导管内乳头状黏液瘤中被认为是抑癌基因。

王世雄, 李耀平. 环指蛋白43基因与肿瘤[J]. 国际肿瘤学杂志, 2016, 43(1): 23-25.

Wang Shixiong, Li Yaoping. Ring finger protein 43 gene and cancer[J]. Journal of International Oncology, 2016, 43(1): 23-25.

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